| 摘要: |
| 目的：探讨新生儿重症监护室（NICU）医院获得性感染病原菌监测及多重耐药相关影响因素。方法：收集我院2015年12月至2019年12月NICU多重耐药菌和医院获得性感染病原菌感染患者病历资料，回顾性分析发生感染的情况，并根据其感染是否为多重耐药进行分组并行多因素分析。结果：NICU共有患儿1 207例，发生医院获得性感染106例，感染率为8.78%。其中呼吸道感染以铜绿假单胞菌、金黄色葡萄球菌和肺炎克雷伯菌为主，分别为32株（36.36%）、14株（15.91%）和10株（11.36%）；败血症病原菌分布以铜绿假单胞菌、金黄色葡萄球菌和肺炎克雷伯菌为主，分别为10株（25.00%）、8株（20.00%）和8株（20.00%）。单因素及多因素Logistic回归分析显示，胎龄<34周、Apgar评分<7分、抗菌药物使用种类≥3种及抗菌药物使用时间≥7 d是NICU中多重耐药菌感染的危险因素。结论：对NICU获得性感染病原菌及多重耐药菌感染的的患儿应加强医院感染监测与护理干预，针对危险因素采取有效的预防措施，以降低NICU获得性感染病原菌及多重耐药菌感染发生率。 |
| 关键词: 新生儿重症监护室 获得性感染病原菌 多重耐药菌 感染 |
| DOI：doi:10.13407/ j.cnki.jpp.1672.108X.2021.09.005 |
|
| 基金项目: |
|
| Monitoring of Pathogens of Hospital-Acquired Infection in Neonatal Intensive Care Unit and Influencing Factors of Multi-Drug Resistance |
| Wang Pinpin, Chang Jing, Wang Guangzhou, Huang Nannan, Yu Fengqin |
| (Women & Infants Hospital of Zhengzhou, Henan Zhengzhou 450012, China) |
| Abstract: |
| Objective: To probe into the monitoring of pathogens of hospital-acquired infection in neonatal intensive care unit (NICU) and influencing factors of multi-drug resistance. Methods: Medical records of patients with multi-drug resistant bacteria and hospital-acquired infection in NICU of our hospital from Dec. 2015 to Dec. 2019 were collected. The occurrence of infection was analyzed retrospectively, multivariate analysis was performed based on whether the infection was multi-drug resistance or not. Results: There were 1,207 children in NICU and 106 cases of hospital-acquired infection occurred, with an infection rate of 8.78%. Respiratory tract infection was dominated by Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumoniae, with 32 strains (36.36%), 14 strains (15.91%) and 10 strains (11.36%), respectively. The distribution of sepsis pathogens was dominated by P. aeruginosa, S. aureus and K. pneumoniae, with 10 strains (25.00%), 8 strains (20.00%) and 8 strains (20.00%), respectively. Univariate and multifactorial Logistic regression analysis showed that gestational age <34 weeks, Apgar score <7, categories of antibiotics ≥3 and application duration of antibiotics ≥7 d were risk factors for multi-drug resistant bacteria infection in NICU. Conclusion: For children with hospital-acquired infection and multi-drug resistance in NICU, hospital infection monitoring and nursing intervention should be strengthened, and effective preventive measures should be taken for risk factors to reduce the incidence of hospital-acquired infection and multi-drug resistant bacteria infection. |
| Key words: neonates intensive care unit hospital-acquired infection multi-drug resistant bacteria |
