| 摘要: |
| 目的：探讨某儿童医院严重药品不良反应（ADR）发生特点和规律，为临床合理用药提供参考。方法：收集我院2017-2019年上报的严重ADR报告，对患儿年龄、性别、给药途径、药品种类等相关因素进行统计分析。结果：132例严重ADR中，男85例（64.39%），女47例（35.61%）。121例严重ADR给药途径为静脉用药，10例为口服给药，1例为喷雾剂。132例严重ADR中抗感染药物占比（47.73%）最高，其次为糖皮质激素（9.09%）、维生素类及营养支持类（6.06%）和中药注射剂（6.06%）。132例严重ADR主要累及皮肤及其附件损害，其次为全身性损害。结论：临床应重视儿童严重ADR的监测和报告，尤其是抗感染药物、糖皮质激素、辅助用药和中药注射剂，进一步规范儿童安全合理用药 |
| 关键词: 不良反应 儿童 合理用药 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2022.03.006 |
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| 基金项目: |
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| Analysis on 132 Cases of Severe Adverse Drug Reactions in a Children’s Hospital |
| Wang Fengjiao, Yao Hua, Yan Yinghui |
| (Children’s Hospital of Soochow University, Jiangsu Suzhou 215025, China) |
| Abstract: |
| Objective: To investigate the characteristics and rules of severe adverse drug reactions (ADR) in a children’s hospital, so as to promote the rational drug use in the clinic. Methods: Severe ADR reported in the hospital from 2017 to 2019 were collected, and related factors such as age, gender, route of administration and drug categories were statistically analyzed. Results: Of the 132 cases of severe ADR, 85 cases were males (64.39%) and 47 cases were females (35.61%). The route of administration in 121 cases of severe ADR was intravenous administration, 10 cases were oral administration, and 1 case was spray. Among the 132 cases of severe ADR, anti-infective drugs accounted for the highest proportion (47.73%), followed by glucocorticoids (9.09%), vitamins and nutritional support drugs (6.06%), and traditional Chinese medicine injections (6.06%). One hundred and thirty-two cases of severe ADR mainly involved skin and its accessory damage, followed by systemic damage. Conclusion: Clinical attention should be paid to the monitoring and reporting of severe ADR in children, especially anti-infective drugs, glucocorticoids, vitamins and nutritional support drugs and traditional Chinese medicine injections, so as to further standardize the safe and rational drug use in children |
| Key words: adverse drug reactions children rational drug use |
