| 摘要: |
| 目的：采用Meta分析的方法评估血清维生素D水平与儿童孤独症谱系障碍（ASD）的相关性。方法：计算机全面检索Medline、EMBase、PubMed、Scopus、the Cochrane Library、EBSCO、Web of Science、中国生物医学文献数据库（CBMdisc）、中国知网（CNKI）、万方数据库、维普网等电子数据库，收集有关与维生素D水平与儿童孤独症谱系障碍相关的病例对照研究进行Meta分析，以加权均数差（Weighted Mean Difference，WMD）及其95%CI为合并效应量，应用Review Manager 5.3及Stata 16软件进行Meta分析，并进行发表偏倚评估和敏感性分析。结果：共纳入14篇文献、2 403例参与者（1 135例ASD患儿和1 268例健康对照）。Meta分析结果显示，总体人群中ASD患者血清25-羟基维生素D[25-（OH）D]水平明显低于对照组（WMD=-8.91，95%CI：-12.45~-5.37，P<0.01）。亚组分析结果显示，中国人群中ASD患儿血清25-（OH）D水平明显低于对照组（WMD=-10.81，95%CI：-16.80~-4.82，P<0.01），中东人群中ASD患儿血清25-（OH）D水平明显低于对照组（WMD=-9.35，95%CI：-18.09~-0.60，P=0.04），欧美（不含中东国家）人群中ASD患儿血25-（OH）D水平与对照组比较差异无统计学意义（WMD=-6.22，95%CI：-12.87~0.44，P=0.07）。结论：维生素D缺乏可能是儿童孤独症谱系障碍的危险因素 |
| 关键词: 孤独症谱系障碍 儿童 维生素D 病例对照研究 Meta分析 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2021.07.001 |
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| 基金项目:重庆市卫生计生委医学科研项目,编号2015ZDXM014 |
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| Meta-Analysis of Relationship between Vitamin D and Autism Spectrum Disorders in Children |
| Wang Yue, Ge Dongmei, Cheng Qian, Dai Ying |
| (Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China) |
| Abstract: |
| Objective: To evaluate the relationship between serum vitamin D levels and autism spectrum disorders (ASD) in children by Meta-analysis. Methods: Medline, EMBase, PubMed, Scopus, the Cochrane Library, EBSCO, Web of Science, CBMdisc, CNKI, Wanfang database and VIP database were retrieved to collect case-control studies related to vitamin D levels and ASD in children by Meta-analysis. Weighted mean difference (WMD) and 95% CI were used as the combined effect size, and Meta-analysis was performed by using Rev Man 5.3 and Stata 16.0 software. Publication bias assessment and sensitivity analysis were performed. Results: A total of 14 literature were collected, including 2,403 participants (1,135 children with ASD and 1,268 healthy controls). Meta-Analysis showed that serum 25-hydroxyvitamin D (25-(OH)D) level in children with ASD was significantly lower than that in the control group (WMD=-8.91, 95%CI: from -12.45 to -5.37, P<0.01). The results of subgroup analysis showed that the serum 25-(OH)D level in children with ASD from China was significantly lower than that in the control group (WMD=-10.81, 95%CI: from -16.80 to -4.82, P<0.01), the serum 25-(OH)D level in children with ASD from the Middle East was significantly lower than that in the control group (WMD=-9.35, 95%CI: from -18.09 to -0.60, P=0.04). In European and American countries (except for the Middle East countries), there was no significant difference in serum 25-(OH)D level between children with ASD and the control group (WMD=-6.22, 95%CI: from -12.87 to 0.44, P=0.07). Conclusion: Vitamin D deficiency may be a risk factor for ASD in children. |
| Key words: autism spectrum disorder children vitamin D case-control study Meta-analysis |
