| 摘要: |
| 目的:评估6-巯嘌呤(6-MP)50 mg 规格片剂不同剂量分割的合理性,探讨6-巯嘌呤片剂不同分割法治疗儿童急性淋巴
细胞白血病(ALL)的疗效和不良反应。方法:6-MP 50 mg 规格片剂根据1/ 2、1/ 3、1/ 4 分割方法设为三组,每组10 片药物,分割
后,称质量,计算均数、标准差。选取2015 年3 月至2020 年12 月ALL 病例314 例,根据6-MP 用药情况分为两组,A 组为1/ 2 分
割给药,B 组为1/ 4 分割给药,比较两组患儿年龄、性别、危险度、无复发生存率(RFS) 及维持阶段不良事件(AE) 发生情况。结
果:3 种分割法,1/ 2 片分割距离目标量最接近,离散程度最小;1/ 3、1/ 4 分割方法距离目标量较远,离散程度大。A、B 两组患儿
年龄、性别、危险度分层比较差异无统计学意义,两组患儿6 年EFS 比较差异无统计学意义,A 组和B 组在维持阶段用药过程中
不良事件发生次数比较差异无无统计学意义。结论:1/ 2 药片是进行药物分割的合理方法,可以比较准确得到相应剂量,药片
相对完整,不易造成药品的浪费。以1/ 2(25 mg)为最小分割单位进行给药或是以1/ 4 片(12. 5 mg)为最小分割单位进行给药,
对患者的远期生存率并无影响。两种不同给药方法,并没有增加6-MP 不良反应。 |
| 关键词: 6-巯嘌呤 儿童 急性淋巴细胞白血病 片剂 分剂量 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2023.02.006 |
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| 基金项目: |
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| Comparison of Efficacy and Adverse Reactions of 6-Mercaptopurine Tablets with Different PartitionMethods in Children with Acute Lymphoblastic Leukemia |
| Wang Jiayi, Lin Huiling, Huang Rulin, Lin Yawen, Pan Yong’e, Cao Xuan, Lai Cuihao, Xiao Daidi |
| ((Guangzhou
Women and Children’s Medical Center, Guangzhou 510623, China)) |
| Abstract: |
| Objective: To evaluate the rationality of different doses of 50 mg 6-mercaptopurine (6-MP) tablets, and explore their
efficacy and adverse reactions in the treatment of childhood acute lymphoblastic leukemia (ALL). Methods: According to the 1/ 2,
1/ 3, and 1/ 4 division method, 50 mg 6-MP tablets were divided into three groups, with 10 tablets in each group. After division, the
tablets were weighed and the means and standard deviations were calculated. According to the 6-MP medication situation, a total of 314
cases of ALL from March 2015 to December 2020 treated in our department were selected and divided into two groups. Group A was
given 1/ 2 divided administration, and group B was given 1/ 4 divided administration. The age, gender, risk status, the relapse-free
survival (RFS) and the occurrence of adverse events (AE) in the maintenance stage of the two groups of patients were compared.Results: There were three segmentation methods, 1/ 2 segmentation was the closest to the target, and the degree of dispersion was the
smallest; 1/ 3 and 1/ 4 division methods were far away from the target, and the degrees of dispersion were large. There was no significant
difference in age, gender, and risk stratification between groups A and B. There was no significant difference in the 6-year RFS between
the two groups of patients, and there was no significant difference in the AE between groups A and B. Conclusion: The 1/ 2 pill is a
reasonable division method, and the corresponding dose can be obtained more accurately. The pill is relatively complete, and it is not
easy to cause waste of medicine. Dosing with 1/ 2 tablet (25 mg) as the smallest division unit or 1/ 4 tablet (12. 5 mg) as the smallest
division unit has no effect on the long-term survival rate of patients. The two different administration methods have not increased the
adverse effects of 6-MP. |
| Key words: 6-mercaptopurine children acute lymphoblastic leukemia tablet drug division |
