| 摘要: |
| 目的：回顾性分析2018-2019年某儿童医院静脉用药调配中心登记的抗肿瘤药物不合理处方，了解抗肿瘤药物不合理用药情况及药师干预前后不合理处方发生率的变化，为寻找更加有效的干预措施提供支持，保障肿瘤患者用药安全。方法：2018-2019年共收集静脉用药调配中心抗肿瘤药物处方3 796张，挑选出不合理处方302张，分析2年内抗肿瘤药物不合理处方。结果：不合理处方类型分别是身高及体质量错误、药物剂量错误、药物使用时间错误、药物使用浓度错误、配伍禁忌（溶媒种类选择错误）、重复用药、溶媒规格错误、医嘱录入错误、药物使用途径错误，药师干预前后对比，不合理用药发生率降低不明显（χ2=0.865，P＞0.05）。结论：化疗药的细胞毒性特点使其在使用中存在高风险，医嘱审核准确率也要求更高，虽然药师短期干预效果在统计学方面不明显，但为了让肿瘤患儿在化疗过程中能得到更加安全的保障，药师需要不断在工作中总结经验，完善审方措施和干预方法。 |
| 关键词: 静脉药物调配中心 抗肿瘤药物 不合理处方 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2023.02.007 |
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| 基金项目: |
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| Analysis of Irrational Prescriptions of Antineoplastic Drugs in Intravenous Admixture Service Center of a Children's Hospital |
| Wang Xuexian, Yu Liting, Zhang Shunguo, Wu Juan |
| (Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China) |
| Abstract: |
| Objective: To understand the irrational use of antineoplastic drugs in intravenous admixture service center in 2018 and 2019, compare the change of the incidence of irrational prescriptions in two years after pharmacist intervention, provide support for finding more effective intervention mechanism to ensure the safety of drug using in cancer patients. Methods: The total number of anti-tumor drug prescriptions was 3,796, including 302 irrational prescription. Referring to the relevant information, χ² test was used to classify the irrational prescription of antineoplastic drugs in two years. Result: Error type ware high or weight error, wrong drug dosage, wrong medication time, wrong drug concentration, incompatibility, repeated use of drugs, solvent error, medical order input error, wrong route of drug use. The incidence of irrational drug use did not decreased significantly before and after pharmacist intervention (χ²=0.865, P>0.05). Conclusion: Due to the cytotoxicity of chemotherapeutic drugs, there are high risks in use, and the accuracy of doctor’s order review is also required to be higher, although the short-term intervention effect of pharmacists is not statistically obvious. Although the effect of intervention was not statistically significant, in order to ensure the safety of children with cancer in the process of chemotherapy, pharmacists need to sum up experience in the work to update the prescription review measures and intervention methods. |
| Key words: pharmacy intravenous admixture service antineoplastic drugs unreasonable prescription |
