| 摘要: |
| 目的:探讨新生儿使用静注人免疫球蛋白(IVIG)后乙肝核心抗体(HBcAb)的变化。方法:采用回顾性研究方法,收集我
院2019-2020 年使用IVIG 的住院新生儿病历,分析使用IVIG 前后患儿HBcAb 的变化。结果:共收集43 例患儿,其中5 例使用
IVIG 前后HBcAb 均呈阳性,10 例使用IVIG 前后HBcAb 均呈阴性,18 例使用IVIG 后HBcAb 由阴性转为阳性,10 例使用IVIG
后因未进行乙肝5 项复测未知HBcAb 的变化。结论:输注IVIG 会引起新生儿HBcAb 水平升高,提示对输注IVIG 的患儿进行
抗体被动转移的排除具有重要意义。 |
| 关键词: 静注人免疫球蛋白 乙肝核心抗体 抗体被动转移 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.03.013 |
|
| 基金项目: |
|
| Effect of Intravenous Immunoglobulin on Hepatitis B Core Antibody in Neonates |
| Yang Lin, Yang Guang, Deng Tao |
| (Panzhihua Maternal and Child Health Hospital, Sichuan Panzhihua 617000, China) |
| Abstract: |
| Objective: To investigate the changes of hepatitis B core antibody (HBcAb) in newborns after intravenous immunoglobulin
(IVIG). Methods: Retrospective research method was conducted in this study to collect medical records of newborns who had IVIG in
our hospital from 2019 to 2020, and the changes of HBcAb before and after using IVIG were compared. Results: Among 43 hospitalized
children treated with IVIG, 5 children were HBcAb positive before IVIG treatment; HBcAb was still negative in 10 children after IVIG
treatment; HBcAb was positive in 18 children after IVIG;10 children were not retested for hepatitis B after IVIG, so the changes of
HBcAb were unknown. Conclusion: Infusion of IVIG can increase the level of HBcAb in neonates, which suggests that it is of great
significance to eliminate passive transfer of antibodies in neonates with IVIG. |
| Key words: intravenous immunoglobulin hepatitis B core antibody passive antibody transfer |
