| 摘要: |
| 线粒体是双侧膜包被的细胞器,控制氧化磷酸化 (oxidative phosphorylation,OXPHOS)、脂肪酸氧化、三羧酸循 环(Krebs 循环)等多种代谢过程,还参与维持钙离子稳定、 氧化还原信号传递、活性氧簇的生产和调节、细胞凋亡等体 内多种重要的病理生理过程,线粒体功能一旦受损,机体功 能就会受到影响。 原发性线粒体病(primary mitochondrial disease,PMD)是指线粒体 DNA(mitochondrial DNA,mtDNA) 或编码电子传递链的核 DNA(nuclear DNA,nDNA)变异导 致氧化磷酸化障碍而引发的一组系统性疾病。 在临床工作 中,也常见到一些疾病具备 PMD 的某些或所有表型,却并 未找到与 OXPHOS 相关的 mtDNA 或 nDNA 突变,这种现象 被称为继发性线粒体功能障碍( secondary mitochondrial dysfunction,SMD)[1-2] 。 |
| 关键词: |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.12.014 |
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| 基金项目: |
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| Determination and Treatment of Secondary Mitochondrial Dysfunction |
| Li Shengrui, Qiu Yinfeng, Jiang Li, Guo Yi |
| (Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China) |
| Abstract: |
| Objective: To evaluate the efficacy and safety of 2% crisaborole ointment in the treatment of mild to moderate atopic dermatitis in children. Methods: A total of 84 children with mild to moderate atopic dermatitis were randomly divided into 47 cases in the treatment group and 37 cases in the control group, respectively treated with 2% crisaborole ointment+emollients and emollients alone for 4 weeks. The effective rate and degree of pruritus improvement in two groups were compared. Results: The effective rate of treatment group and control group were respectively 72. 34% and 27. 03%, with statistically significant difference (P<0. 01). The score of pruritus in the treatment group was significantly improved compared with the control group, with a particular predominance of improvement in nocturnal pruritus and dynamic pruritus score. The improvement rate of pruritus in the treatment group was 63. 83%, significantly higher than 13. 51% in the control group. Adverse drug reactions were rare, only transient local stimulation. Conclusion: 2% crisaborole ointment is safe and effective in the treatment of mild to moderate atopic dermatitis in children. |
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