| 摘要: |
| 目的:了解某院新生儿科2019-2021 年多重耐药菌构成及耐药情况,为临床合理使用抗菌药物提供参考。方法:收集某
院2019-2021 年新生儿科154 例新生儿发生多重耐药感染的细菌监测数据,分别从多重耐药检出率、一般情况、标本来源分布、
多重耐药菌株构成等方面进行分析。结果:2019-2021 年154 例新生儿共检出多重耐药菌株166 株,痰液、血液、支气管分泌物
占标本来源构成的前三位。以早产儿及低出生体质量儿发生多重耐药菌感染占比较大,检出的多重耐药菌以产超广谱β-内酰
胺酶菌(ESBLs)的大肠埃希菌和肺炎克雷伯菌为主,检出率总体呈下降趋势。药敏试验结果显示大肠埃希菌、肺炎克雷菌对头
孢呋辛、头孢曲松耐药率100%,对厄他培南、亚胺培南的敏感率100%。结论:某院新生儿科2019-2021 年多重耐药菌感染的病
原菌以革兰阴性菌为主,且对大部分抗菌药物产生耐药。 |
| 关键词: 新生儿 多重耐药 感染 抗菌药物 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.05.013 |
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| 基金项目: |
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| Pathogenic Characteristics of Multi-Drug Resistance in Neonatal Department of a Hospital from 2019 to 2021 |
| Zhao Hua, Gong Zhanchao, Du Xiaoqun, Guo Shenglan, Lin Chuanzhong, Luo Chongbin |
| (Huadu District People’s Hospital of Guangzhou, Guangzhou 510800, China) |
| Abstract: |
| Objective: To understand the composition and use of multiple drug-resistant bacteria in neonatal department of a hospital,
and to guide the rational use of antibiotics in clinic. Methods: The bacterial surveillance results of multiple drug resistance infection in
154 newborns in the department of neonatal department of a hospital from 2019 to 2021 were analyzed from the detection rate of multiple
drug resistance, the general condition of newborns, the source distribution of samples, and the composition of multiple drug resistant
strains. Results: A total of 166 strains of multiple drug-resistant bacteria were detected from the 154 neonates from 2019 to 2021, and
the top 3 sources of samples were sputum, blood, and bronchial secretions. The incidence of multiple drug resistance infection was
higher in premature and low birth weight infants, and the main multi-drug resistant bacteria detected were producing ESBLs Escherichia
coli and Klebsiella pneumoniae. The detection rate showed downward trend in general. The drug sensitivity results showed that the
resistance rate of Escherichia coli and Klebsiella pneumoniae to cefuroxime and ceftriaxone was 100%, and the sensitive rate to ertapenem
and imipenem was 100%. Conclusion: The main pathogens infected by multiple drug-resistant bacteria in neonatal department of the
hospital are Gram-negative bacteria and are resistant to most antibiotics. |
| Key words: newborn multi-drug resistance infection antibiotics |
