| 摘要: |
| 目的:系统评价输血与极低出生体质量新生儿发生坏死性小肠结肠炎( NEC) 的相关性。方法:计算机检索EMBase、
PubMed、the Cochrane Library 数据库等收集极低出生体质量新生儿输血相关性NEC 的病例研究及随机对照试验,检索时限从建
库至2021 年12 月。由2 名评价者独立筛选文献、提取资料和评估方法学质量后,采用RevMan 5. 3 软件进行Meta 分析。结果:
本研究最终纳入17 篇文献,其中3 篇为队列研究,14 篇为病例对照研究。17 篇文献中,3 篇研究结果提示输血可增加极低出生
体质量新生儿发生NEC 的风险,14 篇提示输血并未显著增加极低体质量新生儿发生NEC 的风险。在合并纳入17 篇文献研究
结果后,发现输血并未显著增加极低出生体质量新生儿发生NEC 的风险(OR= 1. 44,95%CI 0. 87~2. 37,P>0. 05)。结论:输血
并未显著增加极低出生体质量新生儿发生NEC 的风险。 |
| 关键词: 极低出生体质量新生儿 坏死性小肠结肠炎 Meta 分析 输血 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.05.009 |
|
| 基金项目: |
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| Transfusion-associated Necrotizing Enterocolitis in Very Low Birth Weight Infants: Meta-Analysis ofObservational Data |
| Liu Ye, Bu Jun |
| (Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China) |
| Abstract: |
| Objective: To evaluate the relationship between blood transfusion and the incidence of necrotizing enterocolitis (NEC) in
very low birth weight infants. Methods: Several databases, such as Embase, PubMed and the Cochrane Library, were retrieved to
obtain relevant case studies and randomized controlled trials of transfusion-related NEC in very low birth weight infants, and other sources
for case studies and randomized controlled trials related to blood transfusion-induced NEC in very low birth weight infants from the
database establishment to December 2021. The relevant literature, data, and methodological quality were extracted and evaluated by two
reviewers independently. Meta-analysis was conducted using RevMan 5. 3 software. Results: In total, 17 articles were included in this
study, 3 of which were cohort studies, and 14 of them were case control studies. Among the 17 studies, three suggested that blood
transfusion could significantly increase the risk of NEC in very low birth weight infants, while 14 suggested that blood transfusion did not
significantly increase the risk of NEC in very low birth weight infants. After combining the results of 17 literatures, it was found that
blood transfusion did not significantly increase the risk of NEC in very low birth weight newborns (OR=1. 44, 95%CI 0. 87-2. 37, P>
0. 05. Conclusion: Blood transfusion cannot significantly alter the risk of NEC in very low birth weight neonates. |
| Key words: very low birth weight infant necrotizing enterocolitis Meta-analysis blood transfusion |
