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| 英夫利昔单抗联合硫唑嘌呤治疗儿童克罗恩病的药学监护 |
| 李柳珠1,2,李亦君1,杨巧玲1,李志玲1,孙华君1,黄建权1 |
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| (1. 上海市儿童医院,上海交通大学附属儿童医院,上海 200062;2. 广东医科大学附属第二医院,广东湛江 524000) |
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| 摘要: |
| 目的:探讨临床药师在儿童克罗恩病个体化治疗中的药学监护作用。方法:1 例克罗恩病患儿拟应用英夫利昔单抗联合
硫唑嘌呤治疗;临床药师以免疫调节治疗方案的选择、给药剂量的调整及药品不良反应监测等为切入点,结合基因检测,根据患
儿实际情况,配合临床制定个体化给药方案及监护计划。结果:临床药师协助临床医师制定了合理的治疗方案,使患儿症状得
到控制,降低了药物发生不良反应的风险。结论:在临床治疗过程中,临床药师发挥药学专业优势,优化给药方案,可减少药物
不良反应,促进临床合理用药。 |
| 关键词: 克罗恩病 英夫利昔单抗 硫唑嘌呤 药学监护 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.05.004 |
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| 基金项目: |
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| Pharmaceutical Care of Infliximab Combined with Azathioprine in the Treatment of Crohn’s Disease in a Child |
| Li Liuzhu1, 2, Li Yijun1, Yang Qiaoling1, Li Zhiling1, Sun Huajun1, Huang Jianquan1 |
| (1. Shanghai Children’ s Hospital, Children’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200062, China; 2. The Second Affiliated Hospital of Guangdong Medical University, Guangdong Zhanjiang 524000, China) |
| Abstract: |
| Objective: To explore the role of clinical pharmacists in the individualized treatment and pharmaceutical care of Crohn’s
disease in a child. Methods: With the selection of immunomodulatory treatment plan, dosage adjustment and adverse drug reaction
monitoring as the entry point, combined with genetic testing, clinical pharmacists formulated individualized dosing plans and monitoring
plans according to the actual conditions of the patients and cooperated with the clinic. Results: The clinical pharmacist assisted the
clinic in formulating a reasonable treatment plan based on the actual situation of the patient, so that the patient’ s symptoms were
controlled and the occurrence of adverse drug reactions was reduced. Conclusion: In the process of clinical treatment, clinical
pharmacists have exerted their professional advantages in pharmacy, optimized clinical dosing regimens, reduced adverse drug reactions,
and promoted rational clinical use of drugs. |
| Key words: Crohn’s disease infliximab azathioprine pharmaceutical care |
