| 摘要: |
| 目的：通过观察1例13岁儿童患者应用抗结核药物导致药物性肝损伤（DILI）的治疗过程，探讨临床药师在疾病预防和治疗中的作用。方法：临床药师参与1例儿童应用抗结核药物致DILI的治疗过程，根据抗结核药物治疗药物监测（TDM）结果提出用药建议，调整儿童抗结核药物的治疗方案。结果：临床医师部分采纳药师建议，调整用药方案，患儿病情和肝损伤明显改善。结论：TDM是临床药师参与药物治疗的有效技术手段，可保障疾病治疗过程中的用药安全有效。 |
| 关键词: 药物性肝损伤 抗结核药物 治疗药物监测 |
| DOI：doi:10.13407/ j.cnki.jpp.1672.108X.2022.08.002 |
|
| 基金项目:湖南长沙市2019 年第二批重点研发、平台和人才科技计划项目,编号kq1907019 |
|
| Adjustment of Treatment Regimen for a Child with Anti-Tuberculosis Drugs-Induced Liver Injury Based on Therapeutic Drug Monitoring |
| Lu Hong, Shi Qunzhi, Wu Ge, Liu Fangqun |
| (Changsha Central Hospital Affiliated to University of South China, Changsha 410004, China) |
| Abstract: |
| Objective: To probe into the role of clinical pharmacists in disease prevention and treatment through the treatment process of a 13-year-old child with drug-induced liver injury (DILI) induced by anti-tuberculous drugs. Methods: The clinical pharmacists participated into the treatment process of a child with DILI induced by anti-tuberculous drugs, put forward suggestions according to the results of therapeutic drug monitoring (TDM) on anti-tuberculous drugs, and adjusted the treatment regimen of anti-tuberculosis drugs in children. Results: The clinicians partly adopted the suggestions by clinical pharmacists and adjusted the medication regimen, the disease conditions and liver function of the children were significantly improved. Conclusion: TDM is an effective technical means for clinical pharmacists to participate into drug treatment, which can ensure the safety of drugs in disease treatment |
| Key words: drug-induced liver injury anti-tuberculosis drugs therapeutic drug monitoring |
