| 摘要: |
| 目的：探讨癫痫患儿的用药依从性现状，并分析其影响因素。方法：选取2021年1-9月在我院门诊或住院治疗的癫痫患儿，按自愿原则，由癫痫患儿监护人完成Morisky用药依从性问卷，自行设计的患儿一般情况调查问卷以及监护人用药知识、用药信念及用药支持问卷，采用多因素Logistic回归分析用药依从性情况的影响因素。结果：通过微信平台共收集有效问卷107份，患儿年龄（6.75±2.76）岁，用药依从性水平为（6.42±1.20）分，用药依从性较低34例（31.78%），依从性中等54例（50.47%），依从性较高19例（17.76%）。患儿监护人用药知识得分（19.85±4.77）分，56.07%监护人用药知识处于中等水平。30.84%患儿监护人用药信念处于低水平，认为用药弊大于利；31.78%监护人用药支持行为差。Logistic回归分析结果显示，用药支持度影响用药依从性（OR=1.225，P=0.034）。结论：癫痫作为一种慢性疾病，大部分患儿的用药依从性有待提高，主要表现为漏服药物、擅自改变药物剂量及患儿监护人担心药物不良反应而自行减量或停药等，提高监护人对患儿的用药支持度对提高患儿用药依从性具有重要作用 |
| 关键词: 儿童 抗癫痫药物 用药依从性 调查问卷 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2022.07.006 |
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| 基金项目:儿童医疗保障创新研究项目,编号NCRCCHD-2019-HP-15;重庆市2021 年科卫联合医学科研项目,编号2021MSXM23 |
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| Investigation and Analysis of Medication Adherence and Influencing Factors in Children with Epilepsy |
| Zhou Yan, Wu Qing, Yu Chunfei, Fan Xin |
| (Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China) |
| Abstract: |
| Objective: To explore the status of medication adherence in children with epilepsy and analyze its influencing factors. Methods: Children with epilepsy admitted into outpatient or inpatient department of our hospital from Jan. to Sept. 2021 were extracted, and the Morisky medication adherence questionnaire, self-designed questionnaire on the general data of children with epilepsy, and the questionnaire on medication knowledge, medication belief and medication support of guardians were completed by the guardians of children with epilepsy on a voluntary basis, and the factors influencing medication adherence were analyzed by multi-factor Logistic regression. Results: A total of 107 valid questionnaires were collected through the WeChat platform, the age of the children was (6.75±2.76) years, the medication adherence level was (6.42±1.20) points, the medication adherence was low in 34 cases (31.78%), medium in 54 cases (50.47%) and high in 19 cases (17.76%). The medication knowledge score of the guardians was (19.85±4.77) points, and 56.07% of the medication knowledge of the guardians was at the medium level. And 30.84% of the medication belief of the guardians was at the low level, considering that the harm of medication outweighed the benefit; 31.78% of the guardians had poor medication support behavior. Logistic regression analysis showed that medication support affects medication adherence (OR=1.225, P=0.034). Conclusion: As a chronic disease, the medication adherence of most children with epilepsy needs to be improved, mainly due to the omission of drugs, unauthorized change of drug dose, and the reduction or discontinuation of drugs by the guardians of the children for fear of adverse drug reactions. Improvement on medication support of the guardians for the children plays an important role in improving the medication adherence of the children. |
| Key words: children antiepileptic drugs medication adherence questionnaire |
