| 摘要: |
| 目的:探讨新疆地区癫痫患儿拉考沙胺(LCM)稳态血药浓度的影响因素,初步建立LCM 稳态血药浓度的参考范围,为
临床个体化用药提供参考。方法:收集新疆地区规律服用LCM 并达到稳态血药浓度的4~14 岁癫痫患儿313 例,测定血药浓
度,分析年龄、性别、民族、剂量、合并用药等因素对血药浓度的影响,并初步建立稳态血药浓度的参考范围。结果:新疆地区癫
痫患儿的LCM 浓度剂量比(CDR)无性别和民族差异(P>0. 05);4~6 岁组给药剂量高于7~14 岁组,而CDR 低于7~14 岁组
(P 均<0. 01);LCM 单药组给药剂量和血药浓度低于LCM+其他抗癫痫药物组(P 均<0. 05)。总体LCM 稳态血药浓度参考范围
为2. 02~14. 47 μg/ mL。结论:临床使用LCM 控制和治疗儿童癫痫的过程中,有必要进行治疗药物监测,以便及时调整剂量,更
好地控制癫痫发作。 |
| 关键词: 癫痫 儿童 拉考沙胺 血药浓度 参考范围 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2023.04.002 |
|
| 基金项目:中国抗癫痫协会-CAAE 癫痫科研基金-UCB 基金,编号CU-2022-032。 |
|
| Factors Affecting Steady-State Plasma Concentration of Lacosamide in Children with Epilepsy in Xinjiangand Preliminary Establishment of Reference Range |
| Yu Jing, He Lei, Palati·Reheman, Feng Jirong, Sun Yan |
| ((Children’s Hospital of Xinjiang Uygur Autonomous Region,
Xinjiang Hospital of Beijing Children’s Hospital, Urumqi 830000, China)) |
| Abstract: |
| Objective: To explore the factors affecting the steady-state plasma concentration of lacosamide (LCM) in children with
epilepsy in Xinjiang, and to establish the reference range of steady-state plasma concentration of LCM, so as to provide theoretical basis
for clinical individualized drug use. Methods: The serum drug concentration was collected and measured in 313 children with epilepsy
in Xinjiang who regularly took LCM and reached steady-state blood concentration, and the effects of age, gender, ethnicity, dosage and
combined use on the serum concentration of LCM were analyzed, and the reference range of steady-state serum concentration of LCM was
preliminarily established. Results: There was no significant difference in LCM concentration-dose ratio (CDR) values among children
with epilepsy of different genders and ethnic groups (P>0. 05). The dosage of the 4 to 6 age group was significantly higher than that of
the 7 to 14 age group, and the CDR results of the 7 to 14 age group were significantly higher than that of the 4 to 6 age group (all P<
0. 01). The concentration results of the children in the LCM single drug group were significantly lower than those of the LCM combined
with other antiepileptic drugs groups (all P<0. 05). The reference range of steady-state blood concentration of LCM in this study was
2. 02-14. 47 μg/ mL. Conclusion: During the clinical use of LCM to control and treat epilepsy in children, it is necessary to monitor the
therapeutic drug of LCM in order to adjust its dosage in time and better control epileptic seizures. |
| Key words: epilepsy children lacosamide plasma concentration reference range |
