| 摘要: |
| 目的:探讨细菌性社区获得性肺炎( CAP) 婴儿外周血中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、单核细胞与淋巴细胞比值(MLR)、C 反应蛋白(CRP)及降钙素原(PCT)与病情及预后的相关性。 方法:选取我院 2020年 11 月至 2022 年 5 月收治的 150 例细菌性 CAP 婴儿,检测患儿外周血 NLR、PLR、MLR、CRP、PCT 水平和小儿危重评分(PCIS),采用 Spearman 分析 NLR、PLR、MLR、CRP、PCT 与患儿 PCIS 及临床预后的相关性,并采用受试者工作特征(ROC)曲线分析 NLR、PLR、MLR 评估细菌性 CAP 婴儿病情严重程度及预后的效能。 结果:患儿治疗后外周血 NLR、PLR、MLR 水平均低于治疗前(P<0. 01);轻症组患儿外周血 NLR、PLR、MLR、CRP、PCT 水平均低于重症组(P<0. 01);Spearman 分析结果显示,NLR、PLR、MLR 与 PCIS 评分呈负相关(P 均<0. 01);治疗有效组患儿外周血 NLR、PLR、MLR 水平均低于治疗无效组(P<0. 05)。 结论:细菌性 CAP 婴儿急性期外周血 NLR、PLR、MLR 均升高,与 PCIS 呈负相关,这些指标升高提示预后不良。 NLR、PLR、MLR 对婴儿 CAP 病情及预后的早期评估具指导价值。 |
| 关键词: 社区获得性肺炎 婴儿 炎症标志物 病情评估 预后预测 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2023.09.007 |
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| 基金项目::重庆市科卫联合医学科研项目,编号 2020FYYX126 |
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| Predictive Model for Severity and Prognosis of Bacterial Pneumonia in Infants Based on Peripheral Blood Inflammatory Markers |
| Peng Zhen, Li Linwei, Chen Xue, Miao Hongyun, Yan Xiaoyong |
| (Jiangjin Hospital Affiliated to Chongqing University, Jiangjin Center Hospital, Chongqing 402260, China) |
| Abstract: |
| Objective: To explore the correlation between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP), procalcitonin (PCT) levels in peripheral blood and the severity and prognosis of bacterial community-acquired pneumonia (CAP) in infants. Methods: Totally 150 infants with bacterial CAP admitted into our hospital from Nov. 2020 to May 2022 were selected. NLR, PLR, MLR, CRP and PCT levels in peripheral blood were measured and the pediatric critical illness score (PCIS) of the infants were recorded. Spearman analysis was used to assess the correlation between NLR, PLR, MLR, CRP, PCT, PCIS and clinical prognosis. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the effectiveness of NLR, PLR and MLR in assessing the severity and prognosis of bacterial CAP in infants. Results: NLR, PLR and MLR levels in peripheral blood in children decreased significantly after treatment compared with before treatment (P<0. 01).In the mild group, NLR, PLR, MLR, CRP and PCT levels in peripheral blood were significantly lower than those in the severe group(P<0. 01). Spearman analysis showed that NLR, PLR, MLR were negatively correlated with PCIS score (P<0. 01). NLR, PLR and MLR levels in peripheral blood in the effective treatment group were lower than those in the ineffective treatment group (P< 0. 05). Conclusion: NLR, PLR and MLR levels in peripheral blood of infants with bacterial CAP in the acute stage are elevated , and are negatively correlated with PCIS. The increase of these indicators suggests poor prognosis. NLR, PLR and MLR have guiding value for early assessment of severity and prognosis of infants with CAP. |
| Key words: community-acquired pneumonia infants inflammatory markers severity assessment prognostic prediction |
