| 摘要: |
| 目的:观察艾司氯胺酮超前镇痛对小儿骨科全麻手术的疗效及安全性。方法:选取2022 年1 月至2023 年1 月于我院行
骨科手术的患儿60 例,以随机数表法将患儿分为对照组和研究组,每组各30 例。对照组给予芬太尼超前镇痛,研究组则给予
艾司氯胺酮超前镇痛。比较两组患儿手术指标、清醒时间、复苏室停留时间、术后儿童镇静(CHW)评分、术后疼痛评分,并记录
两组患儿术后不良反应的发生情况。结果:研究组患儿清醒时间及复苏室停留时间短于对照组;研究组患儿术后15 min、术后
30 min 的CHW 评分低于对照组;研究组患儿术后30 min、术后60 min 及术后120 min 的疼痛评分低于对照组;此外研究组不良
反应总发生率为10. 00%,低于对照组的33. 33%,差异均有统计学意义(P<0. 05)。结论:艾司氯胺酮超前镇痛应用于小儿骨科
全麻手术,能够有效缩短患儿苏醒时间,优化术后早期镇静及镇痛效果,术后不良反应发生率低。 |
| 关键词: 艾司氯胺酮 超前镇痛 骨科全麻手术 安全性 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2024.04.011 |
|
| 基金项目:中国红十字基金会医学赋能公益专项基金2022 年医学赋能与人才培养计划科研项目,编号2022HSZ006。 |
|
| Efficacy and Safety of Esketamine for Preemptive Analgesia in Pediatric Orthopedic Surgery under GeneralAnesthesia |
| Qian Ning, Wei Yunting, Lyu Jinying |
| ((People’s Hospital of Dongyang, Zhejiang Jinhua 322100, China)) |
| Abstract: |
| Objective: To observe the efficacy and safety of esketamine for preemptive analgesia in pediatric orthopedic surgery under
general anesthesia. Methods: A total of 60 children undergoing orthopedic surgery in our hospital from Jan. 2022 to Jan. 2023 were randomly divided into the control group and study group via the random number table method, with 30 cases in each group. The control
group was given preemptive analgesia with fentanyl, while the study group received preemptive analgesia with esketamine. Surgical
indicators, waking time, duration of stay in postoperative room, Children Hospital of Wisconsion ( CHW) sedation score and
postoperative pain score were compared between two groups. Incidence of postoperative adverse drug reactions in two groups was
recorded. Results: Waking time and duration of stay in postoperative room in the study group were statistically shorter than those in the
control group. The CHW scores of study group were lower than those of control group at 15 min and 30 min after surgery; the pain scores
of study group were lower than those of control group at 30 min, 60 min and 120 min after surgery. The total incidence of adverse drug
reactions in the study group was 10. 00%, lower than 33. 33% in the control group, the differences were statistically significant (P<
0. 05). Conclusion: Esketamine for preemptive analgesia in pediatric orthopedic surgery under general anesthesia can effectively
shorten children’s waking time and optimize early postoperative sedative and analgesic effects, with lower incidence of postoperative
adverse drug reactions.
[ |
| Key words: esketamine preemptive analgesia orthopedic surgery under general anesthesia safety |
