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| 儿童非伤寒沙门菌肠炎的耐药性及无症状带菌情况分析 |
| 宋文琳
1,杭晓星
1,2,熊雨兰
1,2,陈博一
1,王妍妍
1,金太伟 |
|
|
| (1.
苏州市吴江区儿童医院,江苏苏州 215200;2.
苏州大学
药学院,江苏苏州 215123) |
|
| 摘要: |
| 目的:分析儿童非伤寒沙门菌肠炎的临床特征、耐药性及恢复期无症状带菌情况,为合理使用抗菌药物提供参考。 方
法:回顾性收集粪培养结果为非伤寒沙门菌的患儿病例资料,按出院时粪培养是否检出非伤寒沙门菌将入组患儿分为转阴组和未
转阴组,分析两组患儿的临床特征、血清型分布、耐药性及恢复期带菌情况。 结果:120 株非伤寒沙门菌中,鼠伤寒血清型(76 株,63. 3%)
最多。 转阴组和未转阴组对抗菌药物的耐药率比较差异无统计学意义(P>0. 05)。 120 例患儿中,76 例(63. 3%)感染多重耐药
非伤寒沙门菌,经抗感染治疗临床症状治愈但粪培养未转阴者占 62. 5%。 结论:本地区儿童非伤寒沙门菌多重耐药菌株比例较
高,应加强监测并规范抗菌药物使用。 恢复期无症状带菌是非伤寒沙门菌感染的常见后遗症,应规范抗菌药物使用疗程,以免
延长带菌周期或诱导细菌耐药。 |
| 关键词: 儿童 非伤寒沙门菌 临床特征 耐药性 无症状带菌 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2024.09.004 |
|
| 基金项目:2022 年度苏州市吴江区“科教兴卫”项目,编号 WWK202206;2022 年度江苏省研究型医院学会精益化用药-石药专项科研项目,
编号 JY202240。 |
|
| DrugResistanceandAsymptomaticCarriageinChildrenwithNon-TyphoidSalmonellaInfection |
| Song
Wenlin
1,
Hang
Xiaoxing
1,2,
Xiong
Yulan
1,2,
Chen
Boyi
1,
Wang
Yanyan
1,
Jin
Taiwei
1 |
| (1.
Children’s
Hospital
of
Suzhou
Wujiang
District,
Jiangsu
Suzhou 215200,
China;
2.
College
of
Pharmaceutical
Sciences,
Soochow
University,
Jiangsu
Suzhou
215123,
China) |
| Abstract: |
| Objective:
To
study
the
clinical
characteristics,
drug
resistance
and
asymptomatic
carriage
of
non-typhoid
Salmonella
enteritis
in
children,
so
as
to
provide
reference
for
rational
use
of
antibiotics.
Methods:
General
clinical
data
of
children
with
non-
typhoid
Salmonella
in
fecal
culture
were
retrospectively
collected.
According
to
the
detection
of
non-typhoid
Salmonella
in
stool
culture
at
discharge,
the
enrolled
children
were
divided
into
the
negative
group
and
positive
group.
Clinical
characteristics,
serotype
distribution,
drug
resistance
and
asymptomatic
carriage
in
two
groups
were
analyzed.
Results:
Among
the
120
non-typhoid
Salmonella
strains,
Salmonella
typhimurium
serotype
(76
strains,
63. 3%)
took
the
lead.
There
was
no
statistically
significant
difference
in
antimicrobial
resistance
between
the
negative
group
and
positive
group
(P>0. 05).
Among
the
120
children,
76
cases
(63. 3%)
were
infected
with
multi-resistant
non-typhoid
Salmonella,
and
62. 5%
were
asymptomatic
carriers
after
anti-infective
treatment.
Conclusion:
The
proportion
of
multi-drug
resistant
strains
of
non-typhoid
Salmonella
in
children
in
this
region
is
high,
the
monitoring
and
use
of
antibiotics
should
be
strengthened.
Asymptomatic
carriage
during
recovery
is
a
common
sequel
to
non-typhoidal
Salmonella
infection,
and
the
course
of
antimicrobial
use
should
be
standardized
to
avoid
prolonging
the
carriage
cycle
or
inducing
bacterial
resistance. |
| Key words: children non-typhoid
Salmonella clinical
characteristics drug
resistance asymptomatic
carriage |
