| 摘要: |
| 目的:利用网络药理学和分子对接技术探讨洁童阴洗液治疗女童外阴阴道炎的关键靶点及信号通路,并分析其作用机
制。方法:检索洁童阴洗液有效成分及相关靶点、女童外阴阴道炎相关靶点,进行网络拓扑学分析,预测筛选洁童阴洗液治疗女
童外阴阴道炎的潜在靶点蛋白与相关信号通路,进行洁童阴洗液主要活性成分与核心靶点的分子对接分析。结果:网络药理学
分析结果提示洁童阴洗液的主要活性成分为槲皮素、木犀草素、汉黄芩素等,涉及肿瘤蛋白p53(TP53)、丝氨酸/ 苏氨酸蛋白激
酶(AKT)1、表皮生长因子受体(EGFR)、白细胞介素(IL)-6 等可能关键靶点,IL-17、核因子-κB(NF-κB)、雌激素等信号通路,为
治疗女童外阴阴道炎的关键作用途径,并通过分子对接分析得到验证。结论:洁童阴洗液可通过多靶点、多途径治疗女童外阴
阴道炎,本研究可为后续实验研究及临床应用提供参考。 |
| 关键词: 女童 外阴阴道炎 洁童阴洗液 网络药理学 分子对接 作用机制 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2024.12.002 |
|
| 基金项目:国家重点研发计划,编号2017YFC1703205。 |
|
| Mechanism of Jietongyin Lotion in the Treatment of Vulvovaginitis in Girls Based on Network Pharmacology and Molecular Docking Technology |
| Shu Jing1,2, Liu Yanfeng1, Liu Jing2, Yang Yang2 |
| (1. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; 2. National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing 100045,
China) |
| Abstract: |
| Objective: To explore the key target and signal pathway of Jietongyin lotion in the treatment of vulvovaginitis in girls by
using network pharmacology and molecular docking technology, and to analyze its mechanism. Methods: The active components and
related targets of Jietongyin lotion and related targets of vulvovaginitis in girls were retrieved for network topology analysis. The potential
target protein and related protein pathways of Jietongyin lotion in the treatment of girls with vulvovaginitis were predicted and screened to
study the molecular docking between the main active components and core targets of Jietongyin lotion. Results: The network
pharmacological analysis suggested that the main active components of Jietongyin lotion were quercetin, mignonin, and baicalein, which
involved tumor protein p53 ( TP53) and serine/ threonine kinase proteins ( AKT) 1, epidermal growth factor receptor ( EGFR),
interleukine (IL)-6 and other possible key targets, IL-17, nuclear factor kappa B (NF-κB), estrogen and other signaling pathways were
the key pathways for the treatment of vulvovaginitis in girls. The results were verified by molecular docking technology. Conclusion:
Jietongyin lotion in the treatment of vulvovaginitis in girls through multi-targets and multi-pathways, which provides theoretical basis for
subsequent experimental studies and clinical application. |
| Key words: girls vulvovaginitis Jietongyin lotion network pharmacology molecular docking mechanism |
