| 摘要: |
| 目的:探讨首都儿科研究所附属儿童医院(以下简称“我院”)血液科患儿药品不良反应(ADR)的发生特点与规律,为血
液相关疾病的儿童用药安全提供参考。方法:统计和分析2022-2023 年我院血液科143 例ADR 报告,包括给药途径、药品种
类、临床表现、ADR 类型及转归等。结果:143 例ADR 报告中,静脉滴注是占比最高的给药途径(74. 82%)。发生ADR 的药品
种类中,免疫抑制剂的ADR 发生率最高( 44. 06%), 其次为抗肿瘤药( 40. 56%)、抗感染药( 11. 19%)。103 例患儿好转
(72. 03%)。3 例( 2. 10%) 为严重ADR。相关性评价为肯定的有12 例( 8. 39%),很可能为81 例( 56. 64%),可能为50 例
(34. 97%)。结论:临床应加强对ADR 的认知和管理,做好ADR 监测,鼓励多学科临床工作人员积极参与ADR 管理,减少ADR
发生率,保障儿童用药安全。 |
| 关键词: 血液 药品不良反应 儿童 影响因素 监护 |
| DOI：doi:10.13407/j.cnki. jpp.1672-108X.2024.11.006 |
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| 基金项目: |
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| Adverse Drug Reaction Reports in Hematology Department of a Children’s Hospital from 2022 to 2023 |
| Cui Ying, Zhong Xuli, Liu Biqing, Zhang Jianmin |
| (Children’s Hospital, Capital Institute of Pediatrics, Beijing 100020,
China) |
| Abstract: |
| Objective: To probe into the occurrence characteristics and regularity of adverse drug reactions (ADR) in children in the
Hematology Department of Children’s Hospital, Capital Institute of Pediatrics (hereinafter referred to as “our hospital”), so as to
provide reference for the medication safety in children with hematology-related diseases. Methods: Statistics and analysis were made on
143 ADR reports from the Hematology Department of our hospital from 2022 to 2023, including the route of administration, types of
drugs, clinical manifestations, ADR types and outcomes. Results: Among 143 ADR reports, intravenous infusion was the most common
route of administration (74. 82%). Immunosuppressive drugs had the highest incidence of ADR (44. 06%), followed by anti-tumor
drugs (40. 56%) and anti-infective drugs (11. 19%). Totally 103 cases showed improvement (72. 03%). There were 3 cases
(2. 10%) of severe ADR. The correlation was evaluated as positive in 12 cases (8. 39%), likely in 81 cases (56. 64%) and possible
in 50 cases (34. 97%). Conclusion: Clinics should strengthen the knowledge and management of ADR and pay attention to the ADR
monitoring, and encourage multidisciplinary clinical staff to actively participate into the management of ADR, so as to reduce the
occurrence of ADR and ensure the medication safety of children. |
| Key words: hematology adverse drug reactions children influencing factors guardianship |
