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| 注射用头孢曲松钠致儿童胆囊假性结石分析及机制探讨 |
| 李欣坪1,王熊2,牛瑞3,张良明1,徐晓微4,王婧雯5,葛洁5 |
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| (1. 攀枝花市中心医院,四川攀枝花 617000;2. 安康市妇幼
保健院,陕西安康 725000;3. 西北妇女儿童医院,西安 710000;4. 旬阳市人民医院,陕西旬阳 725700;5. 空军军医大学第一
附属医院,西安 710032) |
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| 摘要: |
| 目的:分析注射用头孢曲松钠致儿童胆囊假性结石的发生情况和特点,为儿童安全用药提供参考。方法:回顾性分析
2021 年1 月至2024 年5 月空军军医大学第一附属医院收治的10 例使用注射用头孢曲松钠引起儿童胆囊假性结石患儿病例资
料。结果:本研究共纳入了10 例患儿,其中男6 例(60%),女4 例(40%);年龄17~119 个月;注射用头孢曲松钠日剂量0. 9~
3. 0 g;给药剂量56. 18~115. 61 mg/ (kg·d);用药疗程3~12 d;用药至胆囊假性结石出现时间2~10 d。结论:注射用头孢曲松
钠致儿童胆囊假性结石的发生率高于成人,大多数患儿无症状,胆囊泥沙样结石较多,影响因素包含药物因素和机体因素,停药
后在2~63 d 内自行消失,因此在使用注射用头孢曲松钠过程中应注意识别高危因素,避免出现此类不良反应。 |
| 关键词: 注射用头孢曲松钠 儿童 胆囊假性结石 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.11.011 |
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| 基金项目:基金项目:国家自然科学基金资助项目,编号NO72074218。 |
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| Analysis on Biliary Pseudolithiasis in Children Induced by Ceftriaxone Sodium for Injection and Discussionon the Mechanism |
| Li Xinping1, Wang Xiong2, Niu Rui3, Zhang Liangming1, Xu Xiaowei4, Wang Jingwen5,Ge Jie5 |
| (1. Panzhihua
Central Hospital, Sichuan Panzhihua 617000, China; 2. Ankang Maternal and Child Health Hospital, Shaanxi Ankang 725000, China; 3. Northwest Women’s and Children’s Hospital, Xi’an 710000, China; 4. Xunyang People’s Hospital, Shaanxi Xunyang
725700, China; 5. The First Affiliated Hospital of Air Force Medical University, Xi’an 710032, China)) |
| Abstract: |
| Objective: To analyze the incidence and characteristics of biliary pseudolithiasis in children induced by ceftriaxone sodium
for injection, and to provide reference for safe medication in children. Methods: Data of 10 children with biliary pseudolithiasis induced
by ceftriaxone sodium for injection admitted into The First Affiliated Hospital of Air Force Military Medical University from Jan. 2021 to
May 2024 were retrospectively analyzed. Results: A total of 10 children were enrolled, including 6 males (60%) and 4 females
(40%), aged from 17 to 119 months. The daily dose of ceftriaxone sodium for injection was from 0. 9 to 3. 0 g, the dosage given was
from 56. 18 to 115. 61 mg/ (kg·d), with the treatment duration from 3 to 12 d. The time from medication to the appearance of biliary
pseudolithiasis in the gallbladder was from 2 to 10 d. Conclusion: The incidence of biliary pseudolithiasis in children induced by
ceftriaxone sodium for injection is higher in children than that in adults. Most cases are asymptomatic, with sludge-like stones being the
predominant presentation. Risk factors include both drug-related and patient-specific factors. Discontinuation of medication leads to
spontaneous resolution of stones within 2 to 63 d. Therefore, identifying high-risk factors during the use of ceftriaxone sodium for
injection is crucial to avoid such adverse drug reactions. |
| Key words: ceftriaxone sodium for injection children biliary pseudolithiasis |
