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| 基于德尔菲法和层次分析法构建儿童分剂量用药风险指标评价体系 |
| 王馨迎1,宋竞赛1,李帆1,刘青蓝1,高语晨1,赵一鸣2,马伟峰1,任艳丽1,孙楠1,杨文辉 |
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| (1. 郑州大学第三附属医
院,郑州 450052;2. 首都医科大学附属北京儿童医院,北京 100045) |
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| 摘要: |
| 目的:系统构建儿童分剂量用药的风险评估指标体系。方法:调研文献,讨论分剂量风险,依据Likert 5 级评分法构建函
询调查,采用德尔菲法对40 名专家进行两轮线上问卷函询。通过层次分析法对一级指标及三级指标构建结构模型,依据Saaty
1~9 标度法为指标赋值并两两比较,Yaahp 10. 3 分析权重情况。结果:两轮函询问卷回收率均为100. 00%,专家权威系数分别
为0. 80 和0. 82,第二轮协调系数分别为0. 26、0. 26 和0. 27,最终确定4 个一级指标,15 个二级指标,48 个三级指标。层次分析
结果显示,整个矩阵体系中各指标CR 值均在0. 028~0. 034,一致性较高。一级指标中药品拆分基础条件权重(0. 39) 最高,三
级指标中有规范的分装制度规范权重(0. 10)最高。结论:该体系为临床儿童分剂量用药的风险管控提供了标准化工具。 |
| 关键词: 德尔菲法 层次分析法 儿童 分剂量 评价体系 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.11.005 |
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| 基金项目:基金项目:福棠儿童医学发展研究中心儿科用药安全主管(MSO)岗位设置试点研究,编号FTSCR-2022-02。 |
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| Construction of Risk Assessment Indicator System for Dose-Splitting Medication in Children Based onDelphi Method and Analytic Hierarchy Process |
| Wang Xinying1, Song Jingsai1, Li Fan1, Liu Qinglan1, Gao Yuchen1, Zhao Yiming2, Ma Weifeng1, Ren Yanli1,
Sun Nan1, Yang Wenhui1 |
| (1. The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; 2. Beijing
Children’s Hospital, Capital Medical University, Beijing 100045, China) |
| Abstract: |
| Objective: To systematically establish a risk assessment indicator system for dose-splitting medication in children.
Methods: Through literature review and risk assessment of dose-splitting, Delphi method-based consultation survey was developed by
using Likert 5-level scoring method. Two rounds of online questionnaire surveys were conducted among 40 experts. A hierarchical structural model was established via analytic hierarchy process for primary and tertiary indicators, with indicator weighting determined
through Saaty 1 to 9 scaling method and pairwise comparisons, and analyzed by using Yaahp 10. 3 software. Results: Both questionnaire
rounds achieved 100. 00% response rates. Expert authority coefficients were respectively 0. 80 and 0. 82, with second-round coordination
coefficients reaching 0. 26, 0. 26, and 0. 27. The finalized system comprised 4 primary indicators, 15 secondary indicators, and 48
tertiary indicators. Analytic hierarchy process results demonstrated high consistency across the matrix system (CR values from 0. 028 to
0. 034). Among primary indicators, basic requirements for dose-splitting medication showed the highest weight ( 0. 39), while
standardized packaging regulations emerged as the most weighted tertiary indicator (0. 10). Conclusion: The risk assessment indicator
system provides a standardized tool for the risk management of dose-splitting medication in children in clinical practice. |
| Key words: Delphi method analytic hierarchy process children dose-splitting assessment system |
