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| 多西环素治疗低龄儿童肺炎支原体肺炎的有效性与安全性评价 |
| 刘鑫1,2,曾茜2,李新灵1,张潇2,邢波2,赵庆春1,2 |
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| (1. 沈阳药科大学,沈阳 110016;2. 北部战区总医院,沈阳 110016) |
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| 摘要: |
| 目的:探讨多西环素(DOX) 治疗儿童肺炎支原体肺炎( MPP) 的有效性及安全性,分析低龄儿童应用DOX 的安全性。
方法:回顾性分析2023 年1 月至2024 年3 月北部战区总医院收治的MPP 患儿临床资料。根据不同治疗方法分为DOX 组与对
照组,比较两组患儿住院时间、化验检查指标恢复情况及治疗后转归情况。结果:在有效性方面,DOX 组患儿住院时间短于照
组,白细胞水平更好,C 反应蛋白好转时间短于对照组。在安全性方面,与对照组比较,DOX 组肝功能异常发生率较高,胃肠道
反应发生率较低。结论:DOX 治疗MPP 效果较好,肝功能异常发生率较高,但胃肠道不良反应发生率低于单用大环内酯类药
物,可为DOX 在低龄段儿童群体应用提供参考。 |
| 关键词: 多西环素 大环内酯类 肺炎支原体肺炎 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2025.06.011 |
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| 基金项目:中国博士后科学基金面上项目,编号2023M734298;辽宁省自然科学基金联合基金(面上资助计划项目),编号2023-MSLH-354。 |
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| Efficacy and Safety of Doxycycline in the Treatment of Mycoplasma Pneumoniae Pneumonia in Young Children |
| Liu Xin1,2, Zeng Xi2, Li Xinling1, Zhang Xiao2, Xing Bo2, Zhao Qingchun1,2 |
| (1. Shenyang Pharmaceutical University,
Shenyang 110016, China; 2. General Hospital of Northern Theater Command, Shenyang 110016, China) |
| Abstract: |
| Objective: To explore the efficacy and safety of doxycycline (DOX) in the treatment of Mycoplasma pneumoniae pneumonia
(MPP) in children, and to analyze the medication safety in young children. Methods: Retrospective analysis was performed on clinical
data of children with MPP admitted into the General Hospital of Northern Theater Command from Jan. 2023 to Mar. 2024. All children
were divided into the DOX group and control group according to different treatment methods. The length of stay, recovery of laboratory
examination indicators and prognosis after treatment of two groups were compared. Results: Regarding efficacy, the length of stay in the
DOX group was shorter than that in the control group, the white blood cell value level was better, and the improvement time of C-reactive
protein was shorter than that in the control group. Regarding safety, compared with the control group, the proportion of abnormal liver
function was higher and the proportion of gastrointestinal reactions was lower in the DOX group. Conclusion: DOX has a better
therapeutic effect on MPP, with a higher frequency of abnormal liver function, yet the incidence of gastrointestinal adverse drug reactions
is lower than that of macrolides alone, providing reference for the application in younger age groups. |
| Key words: doxycycline macrolides Mycoplasma pneumoniae pneumonia |
