| 摘要: |
| 目的:探讨异功散加味对小儿功能性消化不良(FD)脾虚夹积证的辅助治疗作用及临床应用价值。 方法:回顾性收集我 院 2020-2023 年门诊接诊的 FD 患儿 98 例(FD 组)和同期体检健康儿童 90 例(健康组)。 按治疗方案将 98 例 FD 患儿分为对 照组和观察组各 49 例。 对照组采用多潘立酮混悬液+常规基础治疗,观察组在对照组治疗方案基础上加用异功散加味内服,疗 程 4 周。 治疗 4 周后对两组 FD 患儿的临床相关指标进行比较分析,比较治疗效果、FD 相关症状与脾虚夹积证评分以及血清胃 泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平。 结果:治疗前,FD 组血清 G-17、PGⅠ、PGⅡ水平均低于健 康组(P<0. 01)。 治疗 4 周后,观察组总有效率为 93. 88%,高于对照组的 77. 55%(P<0. 05);两组 FD 相关症状与脾虚夹积证评 分均降低,且观察组均低于对照组(P 均<0. 01);两组血清 G-17、PGⅠ、PGⅡ水平均升高,且观察组高于对照组(P<0. 01)。 结 论:异功散加味对小儿 FD 脾虚夹积证的疗效显著,能改善 FD 相关症状与中医证候,上调血清 G-17、PGⅠ、PGⅡ水平,值得临床 推广应用与深入研究。 |
| 关键词: 异功散 功能性消化不良 胃泌素-17 胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ |
| DOI：10.13407/j.cnki.jpp.1672-108X.2025.03.003 |
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| 基金项目:温州市科学技术科研基金,编号 Y20180733。 |
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| Clinical Value of Modified Yigongsan in the Treatment of Children with Functional Dyspepsia with Syndrome of Malnutrition Due to Spleen Deficiency |
| Wu Jieru, Xu Yaoqi, Xie Shangren |
| (Wenzhou Central Hospital, Zhejiang Wenzhou 325000, China) |
| Abstract: |
| Objective: To probe into the treatment efficacy and clinical value of modified Yigongsan in the treatment of children with functional dyspepsia (FD) with syndrome of malnutrition due to spleen deficiency. Methods: Retrospective analysis was performed on 98 FD children (FD group) admitted into outpatient department of Wenzhou Central Hospital from 2020 to 2023 and 90 healthy children in the same period (normal group). According to different treatment regimens, 98 FD children were divided into the control group and observation group, with 49 cases in each group. The control group was treated with domperidone suspension + conventional basic treatment, while the observation group additionally received Yigongsan based on the control group, the treatment course was 4 weeks. After 4 weeks of treatment, the clinical related indicators of two groups with FD were compared and analyzed. The therapeutic effect, FD-related symptoms and spleen deficiency syndrome score, and the levels of serum gastrin-17 (G-17), pepsinogen Ⅰ (PG-Ⅰ ) and pepsinogen Ⅱ (PG-Ⅱ) were compared. Results: Before treatment, serum G-17, PG-Ⅰ and PG-Ⅱ levels in FD group were lower than those in normal group (P<0. 01). After 4 weeks of treatment, the total effective rate of observation group was 93. 88%, higher than 77. 55% of control group (P<0. 05). The scores of FD-related symptoms and spleen-deficiency syndrome decreased in both groups, and the observation group was lower than the control group (P<0. 01). Serum G-17, PG-Ⅰ and PG-Ⅱ levels increased in both groups, and the observation group was higher than the control group (P<0. 01). Conclusion: The efficacy of Yigongsan in the treatment of FD with syndrome of malnutrition due to spleen deficiency is evident, which can improve the the clinical symptoms and traditional Chinese medicine syndrome, up-regulate serum levels of G-17, PGⅠ and PGⅡ, and is worthy of clinical application. |
| Key words: Yigongsan functional dyspepsia gastrin-17 pepsinogen Ⅰ pepsinogen Ⅱ |
