| 摘要: |
| 目的:总结分析 1 例动脉导管未闭(PDA)新生儿的治疗过程,为 PDA 患儿的治疗和药学监护提供参考。 方法:临床药师 参与 1 例布洛芬联合氢化可的松琥珀酸钠治疗致多器官出血新生儿的治疗,结合文献证据分析出血原因,制定治疗方案,并对 患儿进行药学监护。 结果:患儿痊愈出院,临床药师对患儿家属进行用药教育,2 周后随访。 结论:使用布洛芬治疗 PDA 应注意 出血相关不良反应,尤其是联合使用糖皮质激素时,出血风险增加。 临床药师为患儿提供全链条药学服务,总结药学监护要点, 体现了新生儿重症监护室临床药师的服务价值。 |
| 关键词: 动脉导管未闭 布洛芬 氢化可的松琥珀酸钠 出血 药学监护 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2025.09.008 |
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| 基金项目:河北省医学科学研究课题计划资助,编号 20231691。 |
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| Pharmaceutical Care for a Neonate with Patent Ductus Arteriosus |
| Wen Di, He Ke, Cheng Lijuan, Liu Yang, Gu Liya |
| (The Fourth Hospital of Shijiazhuang, Shijiazhuang 050000, China) |
| Abstract: |
| Objective: To summarize and analyze the treatment process of a neonate with patent ductus arteriosus (PDA), and provide reference for the treatment and pharmaceutical care of PDA in children. Methods: Clinical pharmacists participated into the treatment of a neonate with multiple organ hemorrhage induced by ibuprofen and hydrocortisone sodium succinate therapy. Causative factors for the hemorrhage were analyzed based on literature evidence. The treatment regimen was formulated, and pharmaceutical care was provided. Results: The child recovered and was discharged. The clinical pharmacists provided medication education to the family members. A follow-up assessment by the clinical team was conducted two weeks after discharge. Conclusion: Hemorrhagic adverse reactions warrant careful monitoring during ibuprofen therapy for PDA, particularly when concurrently administered with glucocorticoids, as the risk of bleeding increases. Clinical pharmacists provide comprehensive pharmaceutical care for children, and summarize the key points of pharmaceutical care, which reflects the value of clinical pharmacists in the Neonatal Intensive Care Unit. |
| Key words: patent ductus arteriosus ibuprofen hydrocortisone sodium succinate hemorrhage pharmaceutical care |
