| 摘要: |
| 目的:探讨N-乙酰半胱氨酸(NAC)雾化吸入对早产儿肺炎的临床疗效及抗氧化应激损伤作用。方法:选取2023 年8 月
至2024 年11 月我院新生儿科收治的肺炎早产儿67 例,采用随机数表法分为对照组34 例与观察组33 例。对照组采用常规治
疗,观察组在对照组治疗基础上加用NAC 雾化吸入治疗。收集两组患儿的临床资料、实验室检查结果,比较两组患儿疗效、住
院时间、呼吸机使用时间、不良反应发生情况等临床指标以及氧化应激标志物、肺损伤标志物水平。结果:治疗5~7 d,观察组
总有效率(90. 91%)高于对照组(76. 47%,P<0. 05)。观察组住院时间、呼吸机使用时间短于对照组(P<0. 05)。治疗后,观察组
PaO2 、pH、超氧化物歧化酶2(SOD2)、表面活性物质特异性蛋白-A( SP-A) 高于对照组,PaCO2 、丙二醛( MDA)、E-选择素( Eselectin)
低于对照组(P 均<0. 05),而两组患儿8-异前列腺素F2α(8-iso-PGF2α)、Clara 细胞蛋白(CC16)浓度比较差异无统计学
意义(P>0. 05)。两组患儿均未发现明显不良反应。结论:NAC 雾化吸入治疗早产儿肺炎安全有效,且NAC 的抗氧化作用对肺
损伤可能起保护作用,在早产儿肺炎治疗中具有良好的应用前景。 |
| 关键词: N-乙酰半胱氨酸 早产儿 肺炎 临床疗效 氧化应激 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.07.003 |
|
| 基金项目:重庆市科卫联合面上项目,编号2022MSXM029 |
|
| Adjunctive Role and Antioxidant Effects of N-Acetylcysteine in the Treatment of Premature Infants withPneumonia |
| Zhang Qiongqiong, Deng Lin, Cheng Yanxia, He Ying, Chen Xia |
| ((Jiangbei Campus, the First Affiliated Hospital of Army
Medical University / 958 Hospital of PLA Army, Chongqing 400000, China)) |
| Abstract: |
| Objective: To probe into the clinical efficacy and antioxidant effects of N-acetylcysteine (NAC) in the treatment of
premature infants with pneumonia. Methods: A total of 67 premature infants with pneumonia admitted into the Neonatology Department
of our hospital from Aug. 2023 to Nov. 2024 were extracted to be divided into the control group (34 cases) and observation group (33 cases)
by random number table method. The control group received conventional treatment, while observation group was treated with NAC
atomization inhalation on the basis of the control group. Clinical data and laboratory test results of two groups were collected, and clinical
efficacy, length of hospital stay, duration of ventilator use, occurrence of adverse drug reactions, levels of markers of oxidative stress and
markers of lung injury between two groups were compared. Results: The total effective rate of observation group (90. 91%) was higher
than that of control group (76. 47%) after 5 to 7 d of treatment (P<0. 05). The length of hospital stay and duration of ventilator use in
the observation group were shorter than those in the control group (P<0.05). After treatment, the PaO2, pH, superoxide dismutase 2
(SOD2), and surfactant-specific protein-A (SP-A) levels in observation group were higher than those in control group, while the
PaCO2 , malondialdehyde (MDA), and E-selectin levels were lower than those in the control group ( P < 0. 05). There was no
statistically significant difference in the concentration of 8-isoprostaglandin F2α (8-iso-PGF2α) and Clara cell protein (CC16) between
two groups (P>0. 05). No obvious adverse drug reactions were observed in two groups. Conclusion: NAC atomization inhalation is safe
and effective in the treatment of premature infants with pneumonia, and the antioxidant effects of NAC may protect the pulmonary injury,
which has a good application prospect in the treatment of premature infants with pneumonia. |
| Key words: N-acetylcysteine premature infants pneumonia clinical efficacy oxidative stress |
