| 摘要: |
| 目的:探讨氨溴索联合布地奈德雾化吸入预防早产儿支气管肺发育不良(BPD)的效果及对血清白细胞介素-6(IL-6)、降
钙素原(PCT)及内皮素-1(ET-1)水平的影响。方法:选择我院2023 年1 月至2024 年5 月收治的早产儿106 例,按随机数表法
分为常规组(采用常规预防治疗)和试验组(采用氨溴索联合布地奈德雾化吸入及常规预防治疗) 各53 例,比较两组患儿治疗
相关指标、BPD 发生情况、血气分析指标、肺功能指标、血清学相关指标、不良反应等。结果:试验组吸氧时间、机械通气时间、
BPD 发生率均短于或低于常规组(P<0. 05);两组患儿治疗后动脉血氧分压(PaO2 )、潮气量(VT)水平均升高,动脉血二氧化碳
分压(PaCO2 )、呼吸频率(RR)、吸气峰压(PIP)、IL-6、PCT、ET-1 患儿均降低,且试验组指标升高、降低更明显(P<0. 05);常规组
不良反应发生率(22. 64%)和试验组(35. 85%)比较差异无统计学意义(P>0. 05)。结论:氨溴索联合布地奈德雾化吸入可有效
缩短早产儿吸氧及机械通气时间,降低BPD 发生率,改善血气分析指标、肺功能指标及相关血清学指标,且不增加不良反应。 |
| 关键词: 早产儿 支气管肺发育不良 布地奈德 氨溴索 雾化吸入 血清学指标 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.11.009 |
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| 基金项目:基金项目:张家口市重点研发计划项目,编号2221169D。 |
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| Clinical Study on Ambroxol Combined with Budesonide Nebulization Inhalation in the Prevention ofBronchopulmonary Dysplasia in Premature Infants |
| Li Aiai, Ji Weiqi, Wang Yanyan |
| (Zhangjiakou Maternal and Child Health Hospital, Hebei Zhangjiakou 075000, China) |
| Abstract: |
| Objective: To explore the efficacy of ambroxol combined with budesonide nebulization inhalation in the prevention of
bronchopulmonary dysplasia (BPD) in preterm infants and its effects on the levels of serum interleukin-6 (IL-6), procalcitonin (PCT),
and endothelin-1 (ET-1). Methods: A total of 106 premature infants admitted into our hospital from Jan. 2023 to May 2024 were
selected to be divided into the control group (received conventional preventive therapy) and experimental group (received ambroxol
combined with budesonide nebulization inhalation and conventional preventive therapy) via the random number table method, with 53
cases in each group. The treatment-related indicators, occurrence of BPD, blood gas analysis indicators, lung function indicators,
serological indicators, and adverse drug reactions were compared between two groups. Results: The oxygen inhalation time, mechanical
ventilation time, and incidence of BPD in the experimental group were shorter or lower than those in the control group (P<0. 05). After
treatment, both groups showed an increase in arterial partial pressure of oxygen (PaO2 ) and tidal volume (VT), and a decrease in
arterial partial pressure of carbon dioxide (PaCO2 ), respiratory rate (RR), peak inspiratory pressure (PIP), IL-6, PCT, and ET-1,
and the experimental group showed more conspicuous increases and decreases in these indicators (P<0. 05). The incidence of adverse
drug reactions in the control group (22. 64%) was not statistically different from that in the experimental group (35. 85%, P>0. 05).
Conclusion: The combined use of ambroxol and budesonide nebulization inhalation can effectively shorten the oxygen inhalation time and
mechanical ventilation time in premature infants, reduce the incidence of BPD, improve blood gas indicators, lung function indicators
and serological indicators, without increasing the incidence of adverse drug reactions. |
| Key words: premature infants bronchopulmonary dysplasia budesonide ambroxol nebulization inhalation serological indicators |
