| 摘要: |
| 目的:探讨与延长输注法(PIT)相比,美罗培南优化的两步输注法(OTIT) 治疗新生儿重症感染的疗效。方法:回顾性分析新生儿重症感染使用美罗培南单药治疗的患儿,OTIT 组单次剂量前1/ 2 在0. 5 h 内静脉泵匀速泵入,后1/ 2 在2. 5 h 内静脉泵匀速泵入;PIT 组予单次剂量在3 h 内静脉泵匀速泵入。比较两组患儿治疗后感染相关指标的变化情况,评价治疗后临床疗效和细菌学清除率。结果:OTIT 组24 例,PIT 组29 例,治疗前年龄、体质量、白细胞计数、中性粒细胞百分比、C 反应蛋白和降钙素原等感染指标比较差异无统计学意义(P>0. 05),治疗后的第3、7 天和停药当天上述感染指标比较差异仍无统计学意义(P>0. 05)。OTIT 组细菌学清除率为85. 7%,PIT 组为75. 0%,差异无统计学意义(P>0. 05);OTIT 组和PIT 组临床有效率分别为95. 8%和93. 1%,差异无统计学意义(P>0. 05)。结论:采用美罗培南治疗新生儿重症感染时,与PIT 相比,OTIT 在临床疗效
和细菌学清除率方面无显著优势。 |
| 关键词: 美罗培南 新生儿 延长输注法 优化的两步输注法 重症感染 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.04.007 |
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| 基金项目:无锡市医学重点学科儿科学(新生儿);无锡市市级临床重点专科项目,编号2023SZD-YXB;无锡市药师协会药学科研项目,编号202501005。 |
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| Evaluation on Efficacy of Optimized Two-Step Infusion Therapy of Meropenem in the Treatment of Severe Infection in Neonates |
| Xue Yan, Jin Weilai, Tang Yunfei, Wang Yan, Zhu Kouzhu |
| ((Affiliated Children’s Hospital of Jiangnan University (Wuxi Children’s Hospital), Jiangsu Wuxi 214023, China)) |
| Abstract: |
| Objective: To investigate the efficacy of optimized two-step infusion therapy (OTIT) of meropenem in the treatment of severe infection in neonates compared with the prolonged infusion therapy (PIT). Methods: Retrospective analysis was performed on neonates with severe infection who were treated with meropenem monotherapy. In the OTIT group, the first half of the single dose was infused at a constant rate through an infusion pump within 0. 5 h, and the second half within 2. 5 h; in the PIT group, the single dose was infused at a constant rate through an infusion pump within 3 h. Changes of infection-related indicators in two groups were compared, the clinical efficacy and bacteriological clearance rate after treatment were evaluated. Results: There were 24 cases in the OTIT group and 29 cases in the PIT group. Before treatment, there was no statistically significant difference in age, body mass, white blood cell count, neutrophil ratio, C-reactive protein, and procalcitonin (P >0. 05). On the 3rd , 7th d after treatment and on the day of drug withdrawal, there was still no statistically significant difference in these infection indicators (P>0. 05). The bacterial clearance rate of OTIT group was 85. 7%, while that of the PIT group was 75. 0%, with no statistically significant difference (P>0. 05). The clinical
effective rates in OTIT group and PIT group were respectively 95. 8% and 93. 1%, the difference was not statistically significant (P> 0. 05). Conclusion: Compared with PIT, OTIT of meropenem for severe infection in neonates shows no significant advantages in terms of clinical efficacy and bacterial clearance rate. |
| Key words: meropenem neonates prolonged infusion therapy optimized two-step infusion therapy severe infection |
