| 摘要: |
| 目的:利用无创检测技术评估两种不同药-光间隔时间下海姆泊芬光动力治疗儿童鲜红斑痣的疗效及安全性。方法:本
研究将纳入的262 例患儿分为5 min 组134 例和20 min 组128 例。通过无创检测技术观察两组患儿在相同光敏剂剂量及相同
光照剂量下的临床疗效及不良反应。结果:5 min 组海姆泊芬光动力治疗1 次显效率为85. 1%,20 min 组为24. 2%,差异有统计学
意义(P<0. 05)。治疗后,5 min 组皮肤厚度较20 min 组降低,皮肤密度提高(P<0. 05)。两组组内比较 Ⅰ 型血管模式患儿的有效率
均最高(P 均<0. 01)。5 min 组短期不良反应发生率较20 min 组高(P<0. 05),但均无瘢痕等长期不良反应的发生。结论:无创检
测技术可有效评估海姆泊芬光动力治疗疗效,在同样的光敏剂剂量及光照剂量下,5 min 组疗效及短期不良反应发生率均高于
20 min 组,但无瘢痕等长期不良反应的发生,表明短时输注海姆泊芬在光动力治疗儿童鲜红斑痣中具有可行性与安全性。 |
| 关键词: 鲜红斑痣 光动力 海姆泊芬 无创检测 药-光间隔时间 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.11.001 |
|
| 基金项目:基金项目:国家自然科学基金青年基金项目,编号82003380;重庆市科卫联合医学科研项目面上项目,编号2024MSXM001;中国医药卫生事
业发展基金会和国家皮肤与免疫疾病临床医学研究中心(北京大学第一医院)共同设立海姆泊芬光动力基金项目;重庆市自然科学基金面
上项目,编号cstc2020jcyj-msxmX0110。 |
|
| Clinical Study on Hematoporphyrin Monomethyl Ether in the Treatment of Children with Port Wine Stainat Different Drug-Light Intervals Based on Non-Invasive Detection Technology |
| Tan Chunhua1, Zhang Jian1, Chen Shuang2 |
| (1.Chongqing Health Center for Women and Children, Women and
Children’s Hospital of Chongqing Medical University, National Health Commission Key Laboratory of Birth Defects and Reproductive
Health, Chongqing 401147, China; 2.The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China) |
| Abstract: |
| Objective: To evaluate the safety and efficacy of hematoporphyrin monomethyl ether photodynamic therapy in the treatment
of children with port wine stain at different drug-light intervals based on non-invasive detection technology. Methods: A total of 262
children were enrolled to be divided into 134 cases in the 5 min group and 128 cases in the 20 min group. With the same photosensitizer
dose and light dose, the clinical efficacy and adverse drug reactions in two groups were observed by non-invasive detection technology.
Results: The effective rate of a single treatment of hematoporphyrin monomethyl ether photodynamic therapy in the 5 min group was
85. 1%, while that in the 20 min group was 24. 2%, the difference was statistically significant (P<0. 05). After treatment, the skin
thickness of the 5 min group was significantly lower than that of the 20 min group, and the skin density increased significantly (P <
0. 05). The patients with type Ⅰ vascular pattern had the highest response rate in both groups (P<0. 01). The short-term adverse drug
reactions in the 5 min group were higher than those in the 20 min group (P<0. 05), but no permanent scar occurred in both groups.
Conclusion: Various non-invasive detection techniques can effectively evaluate the efficacy of hematoporphyrin monomethyl ether
photodynamic therapy. With the same photosensitizer dose and light dose, the efficacy and short-term adverse drug reactions in the 5 min
group were higher than those in the 20 min group, but with no permanent scars in both groups, indicating the feasibility and safety of
hematoporphyrin monomethyl ether photodynamic therapy for children with port wine stain. |
| Key words: port wine stain photodynamic therapy hematoporphyrin monomethyl ether non-invasive detection technology drug-light
intervals |
