| 摘要: |
| 目的:探讨胎龄≤32 周且需有创机械通气的早产儿发生宫外生长发育迟缓(EUGR) 的临床特征及独立危险因素,为临
床早期识别与干预提供参考。方法:回顾性分析2021-2023 年我院收治并接受有创机械通气早产儿的临床资料及治疗结局,诊
断为EUGR 的148 例患儿为EUGR 组,以及115 例未诊断EUGR 组的患儿为非EUGR 组,采用多因素logistic 回归分析EUGR 的
独立危险因素。结果:女性、出生体质量低、宫内生长受限,产妇合并妊娠高血压、用氧时间、使用无创治疗时间、达全肠道喂养
时间、配方奶喂养,合并消化道出血、休克、甲状腺功能减退症、贫血及阿奇霉素、利尿剂及丙种球蛋白的使用均与EUGR 的发生
有关。多因素logistic 回归分析显示,使用配方奶喂养(OR=3. 14,P = 0. 04)、女性( OR= 3. 69,P = 0. 02) 和休克( OR= 3. 73,P =
0. 02)是发生EUGR 的独立危险因素。结论:EUGR 的发生由多因素共同作用,本研究表明女性、使用配方奶喂养和休克为有创
机械通气治疗的早产儿发生EUGR 的独立危险因素。 |
| 关键词: 宫外生长发育迟缓 有创机械通气 早产儿 影响因素 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.11.011 |
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| 基金项目: |
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| Analysis of Risk Factors for Extrauterine Growth Restriction in Preterm Infants with Gestational Age ⩽32Weeks Undergoing Invasive Mechanical Ventilation and Development of Predictive Model |
| Zou Lianshuang, Tu Meng, Chen Kaiting, Xi Sha, Hu Ting, Luo Qin |
| (Children’ s Hospital of Chongqing Medical
University, Jiangxi Hospital, Nanchang 330000, China) |
| Abstract: |
| Objective: To investigate the clinical characteristics and independent risk factors for extrauterine growth restriction (EUGR)
in preterm infants with gestational age ⩽32 weeks requiring invasive mechanical ventilation, and to provide reference for early clinical
identification and intervention. Methods: Retrospective analysis was performed on clinical data and treatment outcomes of preterm
infants who were admitted and received invasive mechanical ventilation in our hospital from 2021 to 2023. A total of 148 infants
diagnosed with EUGR were assigned into the EUGR group, and 115 infants without EUGR were assigned into the non-EUGR group.
Multivariate logistic regression analysis was performed to identify independent risk factors associated with EUGR. Results: Factors
associated with the occurrence of EUGR included female, low birth weight, intrauterine growth restriction, maternal pregnancy-induced
hypertension, duration of oxygen therapy, duration of non-invasive ventilatory support, time to achieve full enteral feeding, formula
feeding, and comorbidities such as gastrointestinal bleeding, shock, hypothyroidism, and anemia, as well as the use of azithromycin,
diuretics, and intravenous immunoglobulin. Multivariate logistic regression analysis revealed that formula feeding (OR = 3. 14, P =
0. 04), female (OR=3. 69, P =0. 02), and shock (OR=3. 73, P =0. 02) were independent risk factors for EUGR. Conclusion: The
development of EUGR is the result of the combined effects of multiple factors. This study demonstrates that female, formula feeding, and
shock are independent risk factors for EUGR in preterm infants receiving invasive mechanical ventilation. |
| Key words: extrauterine growth restriction invasive mechanical ventilation premature infants influencing factors |
