| 摘要: |
| 目的:探讨槿柏洗方外洗联合伊曲康唑治疗儿童头癣的疗效及其对炎症反应、不良反应的影响。方法:选取我院2023 年
3 月至2024 年10 月收治的60 例头癣患儿,随机分为对照组和观察组各30 例。对照组给予伊曲康唑治疗,观察组在对照组治
疗基础上加用槿柏洗方。比较两组患儿的临床疗效、治疗前后症状评分(皮损面积、鳞屑程度、瘙痒程度、红斑情况等)、真菌清
除率、炎症因子[白细胞介素-12(IL-12)、肿瘤坏死因子α(TNF-α)、降钙素原(PCT)、C 反应蛋白(CRP)]和不良反应发生情况。
结果:观察组临床疗效优于对照组( P<0. 05)。治疗后,观察组皮损面积、鳞屑程度、瘙痒程度、红斑情况评分、IL-12、TNF-α、
PCT、CRP 水平均低于对照组(P<0. 05)。两组患儿真菌清除率随治疗时间增加而逐渐增加,但差异无统计学意义( P>0. 05)。
两组患儿不良反应发生率比较差异无统计学意义(P>0. 05)。结论:槿柏洗方外洗联合伊曲康唑治疗儿童头癣,不仅有利于改
善临床症状,提高治疗效率,还可降低炎症反应,改善真菌清除效果。 |
| 关键词: 自拟槿柏洗方 伊曲康唑 儿童头癣 炎症反应 不良反应 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.05.010 |
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| 基金项目:基金项目:秦皇岛市科学技术研究与发展计划项目,编号202301A070。 |
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| Clinical Randomized Controlled Study on Jinbai Washing Formula Combined with Itraconazole in theTreatment of Children with Tinea Capitis |
| Jiang Guixian, Li Lin, Wu Bing, Gong Anming, Gao Cunzhi |
| (Qinhuangdao Hospital of Dongfang Hospital, Beijing
University of Chinese Medicine, Hebei Qinhuangdao 066000, China) |
| Abstract: |
| Objective: To investigate the efficacy of Jinbai washing formula combined with itraconazole in the treatment of children with
tinea capitis and its effects on inflammatory response and incidence of adverse drug reactions. Methods: From Mar. 2023 to Oct. 2024,
totally 60 children with tinea capitis admitted into our hospital were extracted to be randomly divided into the control group and observation group, with 30 cases in each group. The control group was treated with itraconazole, while the observation group was given
Jinbai washing formula on the basis of the control group. The clinical efficacy, symptom scores such as skin lesion area, scale degree,
itching degree, and erythema before and after treatment, fungal clearance rate, inflammatory factors such as interleukin-12 (IL-12),
tumor necrosis factor-α (TNF-α), procalcitonin (PCT), and C-reactive protein (CRP), and adverse drug reactions were compared
between two groups. Results: The clinical efficacy of observation group was better than that of control group (P < 0. 05). After
treatment, the scores of skin lesion area, scale degree, itching degree, erythema, and the levels of IL-12, TNF-α, PCT, and CRP in
observation group were lower than those in control group (P<0. 05). The fungal clearance rates of children in two groups increased with
the treatment duration, but the difference was not statistically significant (P>0. 05). There was no statistically significant difference in
the incidence of adverse drug reactions between two groups (P>0. 05). Conclusion: Jinbai washing formula for external application
combined with itraconazole is beneficial for improving clinical symptoms, enhancing treatment efficiency, and reducing inflammatory
responses, thereby improving the efficacy of fungal clearance. |
| Key words: Jinbai washing formula itraconazole children with tinea capitis inflammatory reactions adverse drug reactions |
