| 摘要: |
| 目的:探讨血清乳酸脱氢酶(LDH)联合中性粒细胞与淋巴细胞比值(NLR)及血小板与淋巴细胞比值(PLR)对百日咳患
儿红霉素治疗反应的预测价值。方法:回顾性纳入2024 年1 月至2025 年7 月在我院住院治疗(入院后接受静脉或口服红霉
素≥7 d)的百日咳患儿120 例,根据治疗7 d 后的疗效分为有效组76 例和无效组44 例。比较两组患儿的临床特征及实验室指
标,采用多因素logistic 回归分析影响治疗反应的独立危险因素,绘制受试者工作特征(ROC)曲线评估各指标及联合模型的预
测效能。结果:无效组患儿血清LDH 水平高于有效组,而NLR 和PLR 水平均低于有效组(P 均<0. 05)。多因素logistic 回归分
析显示,高LDH(OR= 1. 011,95%CI 1. 006~1. 016)、低NLR(OR= 0. 284,95%CI 0. 116~0. 694) 和低PLR( OR = 0. 957,95%CI
0. 920~0. 996)是红霉素治疗百日咳无效的独立预测因素。ROC 曲线分析显示,LDH、NLR、PLR 单独预测的曲线下面积(AUC)
分别为0. 758、0. 676、0. 622,三者联合预测的AUC 为0. 829。结论:血清LDH 联合NLR 和PLR 可作为预测百日咳患儿红霉素
治疗反应的有效指标,有助于早期识别治疗反应不良的高危患儿。 |
| 关键词: 百日咳 乳酸脱氢酶 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 预测模型 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.01.010 |
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| 基金项目: |
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| Combined Predictive Value of Serum Lactate Dehydrogenase, Neutrophil-to-Lymphocyte Ratio, andPlatelet-to-Lymphocyte Ratio for Erythromycin Treatment Response in Children with Pertussis |
| Jin Cheng, Gao Tingting, Yang An |
| (Hefei Maternal and Child Health Hospital, Hefei 230000, China) |
| Abstract: |
| Objective: To probe into the predictive value of serum lactate dehydrogenase ( LDH) combined with neutrophil-tolymphocyte
ratio (NLR) and platelet-to-lymphocyte ratio ( PLR) for erythromycin treatment response in children with pertussis.
Methods: A retrospective study was performed on 120 children with pertussis who were hospitalized in our hospital from Jan. 2024 to
Jul. 2025 (with intravenous or oral erythromycin ⩾ 7 d after admission), all patients were divided into the effective group (76 cases)
and ineffective group (44 cases) based on the efficacy after treatment of 7 d. Clinical characteristics and laboratory indicators of two
groups were compared. Multivariate logistic regression analysis was used to identify the independent risk factors influencing the treatment
response. The receiver operating characteristic (ROC) curve was drawn to evaluate the predictive efficacy of each indicator and the
combined model. Results: The serum LDH level of ineffective group was higher than that of effective group, while the NLR and PLR
were both lower than those of effective group (P<0. 05). Multivariate logistic regression analysis revealed that high LDH (OR=1. 011,
95%CI 1. 006 to 1. 016), low NLR (OR=0. 284, 95%CI 0. 116 to 0. 694), and low PLR (OR=0. 957, 95%CI 0. 920 to 0. 996) were
independent predictors of ineffective treatment for pertussis with erythromycin. The ROC curve analysis showed that the areas under the
curve (AUC) for LDH, NLR, and PLR were respectively 0. 758, 0. 676, and 0. 622, while the AUC for the combined prediction of the
three was 0. 829. Conclusion: Serum LDH combined with NLR and PLR can serve as effective indicators for predicting the treatment
response of children with pertussis to erythromycin, and is helpful for early identification of high-risk children with poor treatment response. |
| Key words: pertussis lactate dehydrogenase neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio predictive model |
