| 摘要: |
| 目的:通过检测肺炎支原体肺炎(MPP)患儿血清CC 趋化因子受体3(CCR3)、膜联蛋白A2(ANXA2) 水平,分析二者与
MPP 患儿病情及预后的关系。方法:选取我院2022 年8 月-2024 年8 月收治的148 例MPP 患儿作为MPP 组,另选取同期我院
体检的健康儿童148 例作为对照组。MPP 组患儿按病情严重程度分为轻症组(n = 105) 与重症组(n = 43);根据患儿预后情况
(治疗3 周后)分为预后不良组( n = 41) 和预后良好组( n = 107)。采用多因素logistic 回归分析影响因素,受试者工作特征
(ROC)曲线分析预测效能。结果:MPP 组血清CCR3、ANXA2 水平均高于对照组(P<0. 01);重症组血清CCR3、ANXA2 水平均
升高于轻症组( P<0. 01);预后不良组血清C 反应蛋白( CRP)、降钙素原( PCT)、CCR3、ANXA2 水平均高于预后良好组( P<
0. 01)。血清CRP、PCT、CCR3、ANXA2 水平升高均是MPP 患儿预后不良的危险因素( P<0. 05);血清CCR3、ANXA2 单独及联
合预测MPP 患儿预后的曲线下面积(AUC) 为0. 833、0. 846、0. 935,二者联合预测效能优于单独预测( Z 分别为2. 970、2. 593,
P 分别为0. 003、0. 010)。结论:MPP 患儿血清CCR3、ANXA2 水平均升高,与患儿病情及预后存在紧密联系,且二者联合在预测
MPP 患儿预后不良方面展现出较高临床效能。 |
| 关键词: 肺炎支原体肺炎 CC 趋化因子受体3 膜联蛋白A2 病情 预后 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.05.011 |
|
| 基金项目:基金项目:四川省卫生和计划生育委员会科研课题,编号20PJ567。 |
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| Prognostic Prediction Model and Early Intervention Strategy of Mycoplasma Pneumoniae Pneumonia inChildren Based on Serum CC Chemokine Receptor 3 and Annexin A2 |
| Wang Ting, Fu Xiaomei, Xia Huijuan, Peng Lan |
| (Neijiang First People’s Hospital, Sichuan Neijiang 641000, China) |
| Abstract: |
| Objective: To analyze the correlation between serum CC chemokine receptor 3 (CCR3) and annexin A2 (ANXA2) levels
and the condition and prognosis of children with Mycoplasma pneumoniae pneumonia (MPP) by detecting the CCR3 and ANXA2 levels
in children with MPP. Methods: Totally 148 children with MPP admitted into our hospital from Aug. 2022 to Aug. 2024 were extracted
as the MPP group. Another 148 healthy children undergoing physical examinations at our hospital during the same period were selected
as the control group. According to the severity of condition, all MPP children were grouped into the mild group (n = 105) and severe
group (n =43). Based on the prognosis of children (after 3 weeks of treatment), the children were divided into the poor prognosis group
(n =41) and good prognosis group (n = 107). Multivariate logistic regression was used to analyze the influencing factors, and the
receiver operating characteristic (ROC) curve was employed to analyze the predictive efficacy. Results: The serum CCR3 and ANXA2
levels in MPP group were higher than those in control group (P<0. 01). The serum CCR3 and ANXA2 levels in severe group were
higher than those in mild group (P<0. 01). The serum C-reactive protein (CRP), procalcitonin (PCT), CCR3, and ANXA2 levels in
poor prognosis group were higher than those in good prognosis group (P<0. 01). Elevated CRP, PCT, CCR3, and ANXA2 levels were
risk factors for poor prognosis in children with MPP (P<0. 05). The area under the curve (AUC) for predicting prognosis in children
with MPP with serum CCR3 and ANXA2 were respectively 0. 833, 0. 846 and 0. 935, the combined prediction was better than the single
prediction (Z = 2. 970 and 2. 593, P = 0. 003 and 0. 010). Conclusion: The serum CCR3 and ANXA2 levels are both elevated in
children with MPP, which are closely related to the disease condition and prognosis. The combination of the two has a high efficacy in
predicting poor prognosis in children with MPP.
[Keywords]Mycoplasma pneumoniae pneumonia |
| Key words: Mycoplasma pneumoniae pneumonia CC chemokine receptor 3 annexin A2 disease condition prognosis |
