| 摘要: |
| 目的:探讨血清炎症发生区因子 2(FIZZ2)、肿瘤坏死因子相关凋亡诱导配体(TRAIL)水平变化与支气管哮喘急性发作 期患儿病情及肺功能的关系。 方法:选择我院 2021 年 7 月-2024 年 7 月收治的 96 例支气管哮喘急性发作期患儿作为急性组, 进一步分为轻度组 39 例、中度组 33 例及重度组 24 例;另选 60 例支气管哮喘缓解期患儿作为缓解组,60 例进行常规体检的健 康儿童作为对照组。 采用酶联免疫吸附试验(ELISA)法检测各组血清 FIZZ2、TRAIL、气道炎症因子[肿瘤坏死因子-α(TNF-α)、 白细胞介素 8(IL-8)]水平;肺功能检测仪对患儿的肺功能指标进行测定;Pearson 检验分析急性组患儿血清 FIZZ2、TRAIL 与肺 功能指标、气道炎症因子的相关性;ROC 曲线评估血清 FIZZ2、TRAIL 水平对重度组患儿的诊断效能。 结果:与对照组相比,缓 解组和急性组患儿的血清 FIZZ2、TRAIL、TNF-α、IL-8 水平均升高,且急性组高于缓解组(P<0. 05);急性组患儿随着病情严重程 度的增加,血清 FIZZ2、TRAIL、TNF-α、IL-8 水平逐渐上升(P<0. 05),而第 1 秒用力呼气容积(FEV1)、用力肺活量(FVC)以及最 大呼吸峰流速(PEF)则逐渐下降(P<0. 05)。 急性组患儿血清 FIZZ2 与 TRAIL 水平之间呈正相关(P<0. 05);血清 FIZZ2、TRAIL 水平与 FEV1、FVC、PEF 均呈负相关,与气道炎症因子均呈正相关(P<0. 05)。 血清 FIZZ2、TRAIL 单独及联合诊断重度患儿的 ROC-AUC 分别为 0. 814(95%CI 0. 722~0. 886)、0. 803(95%CI 0. 709~0. 877)、0. 921(95%CI 0. 847~0. 966),联合检测效能优于 单独检测(Z 分别为 2. 163、2. 785,P 均<0. 05)。 结论:支气管哮喘急性发作期患儿血清 FIZZ2、TRAIL 表达上调,与患儿肺功能 指标密切相关,二者联合检测诊断患儿病情程度的效能更高。 |
| 关键词: 支气管哮喘 儿童 急性发作期 炎症发生区因子 2 肿瘤坏死因子相关凋亡诱导配体 肺功能 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2026.03.005 |
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| 基金项目:河南省医学科技攻关计划联合共建项目,编号 LHGJ20210899 |
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| Establishment of Predictive Model for Children with Acute Exacerbation of Bronchial Asthma Based on Serum Found in Inflammatory Zone 2 and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Levels and Early Drug Treatment Strategies |
| Yang Biao, Guo Miao, Zhang Chunzhi, Wang Qia, Jin Chi, Liu Chaocui |
| (Nanyang Second General Hospital, Henan Nanyang 473000, China) |
| Abstract: |
| Objective: To explore the correlation between changes in serum levels of found in inflammatory zone 2 (FIZZ2) and tumor necrosis factor-related apoptosis-inducing ligand ( TRAIL) and the condition, lung function of children with acute exacerbation of bronchial asthma. Methods: From Jul. 2021 to Jul. 2024, a total of 96 children admitted into our hospital with acute exacerbation of bronchial asthma were extracted as the acute group, and the patients in the acute group were divided into 39 cases in the mild group, 33 cases in the moderate group and 24 cases in the severe group. Another 60 children with bronchial asthma in remission were labeled as remission group, and 60 healthy children who underwent routine physical examination were labeled as control group. The levels of FIZZ2, TRAIL, and airway inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin 8 (IL-8) in the serum of each group were detected by enzyme-linked immunosorbent assay (ELISA). The lung function tester was used to measure the lung function indicators of children. The Pearson test was used to analyze the correlation between serum FIZZ2, TRAIL and lung function indicators, airway inflammatory factors in the acute group. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of serum levels of FIZZ2 and TRAIL in the severe group. Results: Compared with the control group, the serum levels of FIZZ2, TRAIL and TNF-α, IL-8 decreased in the remission group and acute group, and the acute group had higher results than those in the remission group (P<0. 05). As the severity of the acute group increased, the serum levels of FIZZ2, TRAIL and TNF-α, IL-8 increased (P<0. 05), while the forced expiratory volume at one second ( FEV1), forced vital capacity ( FVC), and peak expiratory flow rate (PEF) decreased (P<0. 05). There was a positive correlation between serum FIZZ2 and TRAIL in acute group (P<0. 05); and serum FIZZ2 and TRAIL were negatively correlated with FEV1, FVC, and PEF, and positively correlated with airway inflammatory factors (P< 0. 05). The ROC-area under the curve (AUC) value for the individual and combined detection of serum FIZZ2 and TRAIL in diagnosing severely ill children were 0. 814 (95% CI 0. 722 to 0. 886), 0. 803 (95% CI 0. 709 to 0. 877), and 0. 921 (95% CI 0. 847 to 0. 966), respectively. The combined detection had better efficacy than the individual detection (Z values were respectively 2. 163 and 2. 785, P< 0. 05). Conclusion: The expression of serum FIZZ2 and TRAIL in children with acute exacerbation of bronchial asthma are up-regulated and prominently correlated with lung function indicators of children. The combined detection of the two is more effective in diagnosing the disease severity of children. |
| Key words: bronchial asthma children acute exacerbation period found in inflammatory zone 2 tumor necrosis factor-related apoptosis-inducing ligand lung function |
