| 摘要: |
| 目的:探讨血清颗粒蛋白前体(PGRN)、膜联蛋白 A1(ANXA1)水平与儿童肺炎支原体肺炎(MPP)病情严重程度的关系 及联合诊断价值。 方法:前瞻性选取保定市妇幼保健院 2021 年 12 月 1 日-2023 年 12 月 31 日收治的 103 例 MPP 患儿作为 MPP 组,根据病情严重程度分为轻症组 58 例和重症组 45 例。 另选取同期健康儿童 116 例作为对照组。 ELISA 检测血清 PGRN 和 ANXA1。 MPP 患儿血清 PGRN 和 ANXA1 水平与炎症指标的相关性采用 Pearson 相关性分析;多因素 logistic 回归分析重症 MPP 的影响因素;ROC 曲线分析血清 PGRN、ANXA1 对重症 MPP 的诊断价值。 结果:与对照组比较,MPP 组白细胞计数 (WBC)、中性粒细胞百分比(N%)及血清 PGRN、ANXA1 水平均较高(P<0. 05)。 与轻症组比较,重症组 WBC、N%、血清 PGRN、 ANXA1 水平均较高(P<0. 05)。 Pearson 分析显示,MPP 患儿血清 PGRN 和 ANXA1 水平与 WBC、N%呈正相关(P<0. 01)。 多因 素 logistic 回归显示,WBC(OR= 1. 322)、N%(OR= 1. 314)、血清 PGRN(OR= 1. 452)和 ANXA1(OR= 1. 483)均为重症 MPP 发生 的独立危险因素(P<0. 05)。 ROC 结果显示,血清 PGRN 和 ANXA1 单独诊断重症 MPP 的 AUC 分别为 0. 831 和 0. 804,血清 PGRN 和 ANXA1 联合诊断重症 MPP 的特异度为 82. 76%,灵敏度为 88. 89%,AUC 为 0. 895,高于血清 PGRN(Z = 2. 374,P = 0. 017)和 ANXA1(Z = 2. 511,P = 0. 012)单独诊断的 AUC。 结论:PGRN、ANXA1 在 MPP 患儿血清中水平较高,且血清 PGRN、 ANXA1 对重症 MPP 具有较高诊断价值,有助于临床诊治。 |
| 关键词: 肺炎支原体肺炎 严重程度 颗粒蛋白前体 膜联蛋白 A1 诊断价值 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2026.06.008 |
|
| 基金项目:保定市科技计划项目,编号 2241ZF390 |
|
| Prediction Model and Prevention Strategy for Severe Cases of Children with Mycoplasma Pneumoniae Pneumonia Based on Serum Progranulin and Annexin A1 |
| Sun Mei1 , Ding Yang1 , Liu Xuemei2 , Wen Jing2 , Wang Shijuan3 , Ma Wenying3 |
| (1. Baoding Maternal and Child Health Hospital, Hebei Baoding 071000, China; 2. the 82nd Group Military Hospital of PLA Army, Hebei Baoding 071000, China; 3. Wangdu County Traditional Chinese Medicine Hospital, Hebei Baoding 072450, China) |
| Abstract: |
| Objective: To explore the correlation between the levels of serum progranulin (PGRN) and annexin A1 (ANXA1) and severity of Mycoplasma pneumoniae pneumonia (MPP) in children and the value of combined diagnosis. Methods: Totally 103 children with MPP admitted into Baoding Maternal and Child Health Hospital from Dec. 1st, 2021 to Dec. 31st, 2023 were extracted as the MPP group prospectively, and the patients were divided into the mild group ( n = 58) and severe group ( n = 45) based on the severity of disease condition. Another 116 healthy children during the same period were extracted as the control group. ELISA was applied to detect the serum PGRN and ANXA1. The correlation between serum PGRN and ANXA1 levels and inflammatory markers in children with MPP was analyzed by using Pearson correlation analysis. Multivariate logistic regression was applied to analyze the influencing factors of severe MPP. ROC curve was applied to analyze the diagnostic value of serum PGRN and ANXA1 for severe MPP. Results: Compared with the control group, the MPP group had higher white blood cell (WBC), neutrophil percentage (N%), and serum PGRN and ANXA1 levels (P<0. 05). Compared with the mild group, the severe group had higher WBC, N%, serum PGRN, and ANXA1 levels (P<0. 05). Pearson analysis showed that the serum PGRN and ANXA1 levels in children with MPP were positively correlated with WBC and N% (P<0. 01). Multivariate logistic regression showed that WBC (OR= 1. 322), N% (OR= 1. 314), serum PGRN (OR= 1. 452), and ANXA1 (OR= 1. 483) were independent risk factors for the occurrence of severe MPP (P<0. 05). ROC results showed that the AUC of serum PGRN and ANXA1 for diagnosing severe MPP alone was respectively 0. 831 and 0. 804, the specificity and sensitivity of serum PGRN and ANXA1 combined for diagnosing severe MPP were 82. 76% and 88. 89%, and AUC was 0. 895, which was higher than AUC of individual diagnosis of serum PGRN ( Z = 2. 374, P = 0. 017) and ANXA1 ( Z = 2. 511, P = 0. 012). Conclusion: The serum PGRN and ANXA1 levels in children with MPP are relatively high. Moreover, the serum PGRN and ANXA1 levels have high diagnostic value for severe MPP and are helpful for clinical diagnosis and treatment. |
| Key words: Mycoplasma pneumoniae pneumonia severity progranulin annexin A1 diagnostic value |
