| 摘要: |
| 目的:探讨阿司匹林精准剂量调整对川崎病恢复期患儿的临床意义。 方法:选取我院 2024 年 1 月-2025 年 3 月收治的 104 例川崎病恢复期患儿,以随机数表法分为精准剂量组和固定剂量组各 52 例。 精准剂量组采用阿司匹林精准剂量调整方 案,1 例失访,最终纳入 51 例;固定剂量组采用阿司匹林固定剂量方案,0 例失访,最终纳入 52 例。 比较两组患儿的血小板功 能、系统性免疫-炎症指数(SII)、炎症因子水平、血管内皮功能及安全性。 结果:治疗后,两组患儿血小板聚集率、血小板计数 (PLT)、D-二聚体、SII 以及血清肿瘤坏死因子-α(TNF-α)、内皮生长因子(VEGF)、白细胞介素-18( IL-18)、内皮素-1(ET-1)、白 细胞(WBC)水平均降低(P<0. 05),且精准剂量组均低于固定剂量组(P<0. 05)。 精准剂量组不良反应发生率为 13. 73%(7/ 51), 固定剂量组为 17. 31%(9 / 52),两组比较差异无统计学意义(P>0. 05)。 结论:阿司匹林精准剂量调整对川崎病恢复期患儿的治 疗优势较好,可更有效抑制血小板功能并降低 SII。 |
| 关键词: 阿司匹林 川崎病 血小板功能 系统性免疫-炎症指数 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2026.06.004 |
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| 基金项目:河北省卫生健康委员会资助项目,编号20261289 |
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| Effects of Precise Dose Adjustment of Aspirin on Platelet Function and Systemic Immune-Inflammation Index in Children with Kawasaki Disease in the Recovery Period |
| Bai Yajie, Shao Lili, Ma Ran, Zhang Feifei |
| (Cangzhou Central Hospital, Hebei Cangzhou 061000, China) |
| Abstract: |
| Objective: To probe into the clinical significance of precise dose adjustment of aspirin for children with Kawasaki disease in the recovery period. Methods: A total of 104 children with Kawasaki disease in the recovery period admitted into our hospital from Jan. 2024 to Mar. 2025 were extracted to be divided into the precise dose group and fixed dose group, with 52 cases in each group via the random number table method. In the precise dose group, 1 case was lost to follow-up and 51 cases were enrolled. In the fixed dose group, 0 case was lost to follow-up, and 52 cases were finally included. The platelet function, systemic immune-inflammation index (SII), inflammatory factors, vascular endothelial function and safety were compared between two groups. Results: After treatment, both groups showed a decrease in platelet aggregation rate, platelet count (PLT), D-dimer, SII, and serum tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF), interleukin-18 (IL-18), endothelin-1 (ET-1), and white blood cell (WBC) levels (P<0. 05), and the above indicators in the precise group were lower than those in the fixed dose group (P<0. 05). The incidence of adverse drug reactions in the precise dose group was 13. 73% (7 / 51), while that in the fixed dose group was 17. 31% (9 / 52), with no significant difference between two groups ( P > 0. 05). Conclusion: Precise dose adjustment of aspirin has a better therapeutic advantage for children with Kawasaki disease in the recovery period, which can more effectively inhibit platelet function and reduce SII. |
| Key words: aspirin Kawasaki disease platelet function systemic immune-inflammation index |
