| 摘要: |
| 目的：分析我院新的、严重药品不良反应（ADR）发生的特点和规律，促进儿童安全合理用药。方法：对我院2013-2018年上报国家药品不良反应监测中心的新的、严重的67例儿童ADR报告进行统计分析。结果：1~3岁儿童患者新的、严重ADR发生率较高，共18例（26.87%）；静脉给药途径引发的ADR最多，共47例（70.15%）；引发新的、严重ADR药物种类主要是抗感染药物，共22例（32.84%），其次是抗肿瘤药物，共12例（17.91%）；ADR累及器官或系统主要为消化系统，共17例（25.37%）。结论：我院需加强ADR监测与上报工作，临床用药过程中需注意监测抗感染药物和静脉用药物引发的ADR，规范给药，促进儿童安全合理用药。 |
| 关键词: 不良反应 儿童 新的 严重 安全用药 |
| DOI：doi:10.13407/ j.cnki.jpp.1672-108X.2022.02.007 |
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| 基金项目: |
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| Reports of 67 Cases of New and Severe Adverse Drug Reactions in a Children’s Hospital from 2013 to 2018 |
| Chen Rong |
| (Fuzhou Children’s Hospital of Fujian Province, Fuzhou 350001, China) |
| Abstract: |
| Objective: To analyze the characteristics and regularities of new and severe adverse drug reactions (ADR) in our hospital, so as to promote the safe and rational use of drugs for children. Methods: Statistical analysis was performed on reports of 67 cases of new and severe ADR reported to National ADR Monitoring Center in our hospital from 2013 to 2018. Results: The incidence of new and severe ADR was higher in children aged from 1 to 3 years, with a total of 18 cases (26.87%). The most ADR was induced by intravenous administration, with a total of 47 cases (70.15%). The main drug types of new and severe ADR were anti-infective drugs (22 cases, 32.84%), followed by anti-tumor drugs (12 cases, 17.91%). Organs or systems involved in ADR were mainly the digestive system, with a total of 17 cases (25.37%). Conclusion: Our hospital needs to strengthen the monitoring and reporting of ADR, pay attention to the monitoring of ADR induced by anti-infective drugs and intravenous drugs in the process of clinical drug use, and promote the safe and rational use of drugs in children. |
| Key words: adverse drug reactions children new severe safe drug use |
