| 摘要: |
| 目的：调查分析全国范围内儿科口服药品分剂量现状，了解临床上分剂量最频繁药品的种类与规格，给出改善药品分剂量现状的建议。方法：采用问卷形式，收集国内30家医院2019年12月儿童口服药品医嘱数据，分别从分剂量药品种类、医嘱数量、分剂量规格、最迫切需要规格等方面进行统计与分析。结果：本次参加调查单位口服分剂量药品共计16类282种，最常分剂量种类为抗感染药物、消化系统用药和心血管系统用药，最常分剂量药品为螺内酯片、氯化钾片和呋塞米片等药品。最常分剂量规格为1/2片、1/4片及1/5片，需求最迫切的规格多为1/2片、1/3片、1/4片及1/5片。螺内酯片、呋塞米片等7种药品不仅分剂量工作量大，而且最小分剂量规格≤1/20片。结论：普遍的分剂量现象反映出我国儿童适宜药品较为缺乏。为保障儿童用药安全、有效、可及，药品分剂量工作需要政产学研用多方面共同配合。 |
| 关键词: 儿童 口服药品 分剂量 |
| DOI：doi:10.13407/ j.cnki.jpp.1672-108X.2022.02.008 |
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| 基金项目:基金项目:重大新药创制科技重大专项,编号2018ZX09721003。 |
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| Investigation and Analysis on Drug Manipulation for Pediatric Oral Dosing in Pediatric Hospitals |
| Guan Weiwei1, Song Ziyang1, Mei Dong1, Jia Yuntao2, Chen Zebin3, Wang Xiaoling1 |
| (1. Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China; 2. Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Chongqing 400014, China; 3. Shenzhen Children’s Hospital, Guangdong Shenzhen 518038, China) |
| Abstract: |
| Objective: To investigate and analyze the current status of drug manipulation for pediatric oral dosing in China, to understand the categories and specifications of the most frequent drug manipulation in clinic, so as to provide suggestions for improving the current status of drug manipulation. Methods: Questionnaire survey was used to collect the medical orders of oral drugs for children from 30 hospitals in China in Dec. 2019, and statistical analysis was performed in terms of drug categories, number of medical orders, specifications of drug manipulation and most urgent needs, etc. Results: Totally 16 categories, 282 kinds of drug manipulation for pediatric oral dosing were collected. The most frequently categories of drug manipulation for pediatric oral dosing were anti-infective drugs, digestive system drugs and cardiovascular system drugs. The most frequently drugs of drug manipulation for pediatric oral dosing were spironolactone tablets, potassium chloride tablets and furosemide tablets. The most frequently specifications of drug manipulation for pediatric oral dosing were 1/2, 1/4 and 1/5, the specifications of 1/2, 1/3, 1/4 and 1/5 were most commonly wanted. Spironolactone tablets, furosemide tablets and other 7 kinds of drugs not only had a large workload in drug manipulation, but the minimum drug manipulation specification was less than or equal to 1/20. Conclusion: The widespread phenomenon of drug manipulation for pediatric oral dosing reflects the lack of appropriate drugs for children in China. In order to ensure the safety, effectiveness and accessibility of drugs for children, the work of drug manipulation requires the cooperation of government, enterprises, universities, research institutions and hospitals. |
| Key words: children oral drugs drug manipulation |
