| 摘要: |
| 目的:观察成分输血对贫血早产儿调节性T 淋巴细胞(Tregs)以及临床预后的影响。方法:选取2012年6月至2015年3月湖北省红安县人民医院儿科需要输血治疗的贫血早产儿96例,采用随机数表法分为对照组(浓缩红细胞输注) 和观察组(洗涤红细胞输注)各48例,应用流式细胞仪检测外周血Tregs的比例。结果:输血后两组患儿的输血量、输血次数、输血后血红蛋白以及输血后血细胞压比较差异无统计学意义(P>0.05)。两组输血前Tregs比较差异无统计学意义(P>0.05),输血后对照组Tregs比例比治疗前显著增加(P<0.05),但输血后观察组Tregs比例无显著变化(P>0.05)。观察组呼吸暂停、体质量增加缓慢、喂养困难发生率和住院时间分别为60.4%、22.9%、36.3% 和(32.14±6.21) d,均显著低于对照组的75.0%、39.6%、14.6%和(41.25±8.16)d (P<0.05)。输血后观察组机械辅助通气时间和院内感染发生率均显著低于对照组(P<0.05)。结论:贫血早产儿输注洗涤红细胞后对Tregs无显著影响,并且有利于早产儿贫血临床预后好转,因此符合输血指征的贫血早产儿推荐使用洗涤红细胞纠正贫血。 |
| 关键词: 早产儿 成分输血 调节性T 淋巴细胞 浓缩红细胞 洗涤红细胞 |
| DOI：10.13407/j.cnki.Jpp.1672-108X.2017.04.011 |
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| 基金项目: |
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| The Effect of Different Component Blood Transfusion on Regulatory Cells and Clinical Outcome of Premature Infants with Anemia |
| Xia Jianxin1, Hu Wenhui2 , Huang Rong3 |
| (1. Hong'an County People's Hospital, Hubei Province, Hubei E'zhou 438400, China; 2. E'zhou City Centre Blood Station, Hubei Province, Hubei E'zhou 436000, China; 3. Jianshi County People's Hospital, Hubei Enshi 445300, China) |
| Abstract: |
| Objective: To observe the effect of different component blood transfusion on component blood transfusion on regulatory cells (Tregs) and clinical outcome of premature infants with anemia. Methods: A total of 96 premature infants with anemia who need blood transfusion treatment were enrolled from Hong'an County People's Hospital. All infants were randomly divided into: control group (concentrated red blood cell transfusion, n=48) and observation group (washed red blood cell transfusion, n=48). The proportion of Tregs was detected by flowcytometry analysis. Results: After blood transfusion treatment, there were no significant differences of blood transfusion volume, blood transfusion numbers, hemoglobin content and hematocrit between the two groups (P>0.05). There was no significant difference of proportion of Tregs between the two groups before treatment (P>0.05). After treatment, the proportion of Tregs in control group was significantly increased (P<0.05), but there was no significant difference in treatment group (P>0.05). The dyspnea, weight gain, incidence rate of feeding difficulty, and hospitalization time in observation group were 60.4%, 22.9%,36.3%,and (32.14±6.21) d, respectively, which was lower than those of 75.0%, 39.6%, 14.6%, and (41.25±8.16) d in control group (P<0.05). The mechanical ventilation time and incidence rate of nosocomial infection in observation group were significantly lower than those in control group after blood transfusion (P<0.05). Conclusion: There was no significant effect on Tregs after washing red blood cells transfusion, which was beneficial to the clinical prognosis of premature infants anemia. It is recommended to use washing red blood cells to correct anemia in premature infants. |
| Key words: premature infants component blood transfusion regulatory cells concentrated red blood cell washed red blood cell |
