| 摘要: |
| 目的:探讨我院儿科哌拉西林/他唑巴坦(TZP)、头孢他啶(CAZ)的用药频度(DDDs)与大肠埃希菌(E.coli)、肺炎克雷伯菌(Kpn)、铜绿假单胞菌(PA)耐药率的相关性,为临床合理用药提供参考。方法:应用Excel2007软件,按季度统计2012-2015年TZP、CAZ的DDDs及同期E.coli、Kpn、PA对儿科常用抗菌药物的耐药率。应用SPSS19.0软件,采用Pearson相关性分析方法分析DDDs与耐药率的相关性。结果:TZP的DDDs与E.coli对头孢西丁(FOX)、阿莫西林/克拉维酸(AMC)、头孢呋辛(CXM)的耐药率呈正相关(P均<0.05),与Kpn对AMC、CXM、头孢曲松(CRO)、氨苄西林/舒巴坦( SAM)的耐药率呈正相关
(P均<0.05),与产ESBLs Kpn的分离率呈正相关(P<0.05)。CAZ的DDDs与E.coli、Kpn、PA 的耐药率、产ESBLs率无相关性。结论:我院儿科TZP的DDDs与E.coli、Kpn的耐药率呈正相关,应合理控制其使用。 |
| 关键词: 哌拉西林/他唑巴坦 头孢他啶 大肠埃希菌 肺炎克雷伯菌 铜绿假单胞菌 耐药率 相关性 |
| DOI：10.13407/j.cnki.Jpp.1672-108X.2017.04.012 |
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| 基金项目: |
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| Correlation between Frequency of Drug Use of Piperacillin Tazobactam, Ceftazidime and Three Kinds of Common Gram-Negative Bacteria Resistance in Pediatric Department |
| Ou Renhao, Huang Yuling, Meng Lidi, Xiao Ping |
| (Maternal and Child Health Hospital of Liuzhou, Guangxi Liuzhou 545001, China) |
| Abstract: |
| Objective: To investigation the correlation between the frequency of drug use (defined daily doses, DDDs) of piperacillin tazobactam (TZP), ceftazidime (CAZ) and the resistance rates of Escherichia coli (E.coli), Klebsiella pneumoniae (Kpn) amd Pseudomonas aeruginosa (PA) in the hospital pediatric, so as to provide reference for clinical rational use of antibiotics. Methods: The DDDs of TZP and CAZ and the resistance rates of E.coli, Kpn and PA to some of the commonly used antibiotics in pediatric from 2012
to 2015 were counted quarterly by the Excel2007 software, then their correlation were analyzed by the relevant analytic method of Pearson with SPSS19.0 software. Results: The resistance rates of E.coli to cefoxitin, amoxicillin/clavulanic acid and cefuroxime were positively correlated with the DDDs of TZP (P<0.05). Also, the resistance rates of Kpn to amoxicillin/clavulanic acid, cefuroxime, ceftriaxone and ampicillin/sulbactam, and the isolation rate of producing-ESBLs Kpn were positively correlated with the DDDs of TZP (P<0.05). No correlation between the DDDs of CAZ and the resistance rate of E.coli, Kpn and PA, also the producing ESBLs rate of those bacteria. Conclusion: As resistance rates of E.coli, Kpn and PA are relative to the DDDs of TZP, the use of TZP should be reasonably controlled. |
| Key words: piperacillin tazobactam ceftazidime Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa resistance rate correlation |
