| 摘要: |
| 目的:探讨血浆氨基末端脑钠肽原(NT-proBNP)对新生儿窒息后心力衰竭(HF)的诊断价值。方法:选取2014年1月至2015年3月在我院接受治疗的新生儿窒息患者120例,根据有无HF分为HF组55例和无HF组65例。测定两组患儿血浆NT-proBNP、肌钙蛋白I(cTnI)、乳酸脱氢酶1(LDH1)、肌酸激酶同功酶(CK-MB)水平。结果:HF组NT-proBNP、LDH1、CK-MB和cTnI水平分别为27 944.73(18 042.12,30 981.10)ng/L、(463.29±54.29)U/L、192.04(62.74,223.16)U/L 和0.12(0.04,0.21)mg/L,明显高于无HF组,差异有统计学意义(P<0.05);非条件Logistic回归分析结果显示,NT-proBNP是新生儿窒息后发生HF的独立危险因素(OR=1.482,P<0.05);NT-proBNP诊断新生儿窒息后发生HF的ROC曲线下面积为0.952,95% CI(0.908,0.995);当截断值为13 181 ng/L 时,诊断灵敏度为90.20%,特异性为100%。结论:血浆NT.proBNP对新生儿窒息后心力衰竭有一定诊断价值,对于早期发现窒息后心力衰竭、指导治疗有重要的临床意义。 |
| 关键词: 氨基末端脑钠肽原 新生儿 窒息 心力衰竭 诊断价值 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2017.03.002 |
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| 基金项目: |
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| The Value of Plasma N-Terminal Pro-Brain Natriuretic Peptide in the Evaluation of Heart Failure after Neonatal Asphyxia |
| Li Hongli1 , Wang Min2 |
| (1. Hanchuan Maternal and Child Health Care Hospital of Hubei Province, Hubei Hanchuan 431600, China; 2. Renmin Hospital of Wuhan University Hanchuan Hospital, Hubei Hanchuan 431600, China) |
| Abstract: |
| Objective: To investigate the value of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) in the evaluation of heart failure after neonatal asphyxia. Methods:From January 2014 to March 2015 in our hospital, 120 cases of neonatal asphyxia according to heart failure (HF) were divided into HF group (55 cases) and non-HF group (65 cases). The levels of NT-proBNP, troponin I (cTnI), lactate dehydrogenase 1 (LDH1), creatine kinase isoenzyme (CK-MB) were detected in two groups. Results: The levels of NT-proBNP, LDH1, CK-MB and cTnI were 27,944.73 (18 042.12, 30 981.10) ng/L, (463.29±54.29) U/L, 192.04 (62.74, 223.16) U/L and 0.12 (0.04, 0.21) mg/L in HF group, those were significantly higher than non-HF group, the differences were statistically significant (P<0.05). Non conditional logistic regression equation showed that NT-proBNP was the occurrence of HF after neonatal asphyxia independent risk factor (OR=1.482, P<0.05). NT-proBNP diagnosis of neonatal asphyxia area under the ROC curve for HF was 0.952, 95% CI (0.908, 0.995). When the cutoff value was 13,181 ng/L, the diagnostic sensitivity was 90.20% and specificity was 100%. Conclusion: Plasma NT-proBNP has a certain value in the diagnosis of heart failure after neonatal asphyxia, for early detection of asphyxia combined with heart failure, guiding treatment, has important clinical significance. |
| Key words: NT-proBNP neonate asphyxia heart failure diagnostic value |
