| 摘要: |
| 目的:探讨血清白蛋白(ALB)水平对新生儿败血症患儿预后的影响。方法:将92 例新生儿败血症患儿根据预后情况分为
存活组(62 例)和死亡组(30 例)。在确诊为新生儿败血症时及确诊后的第1、3、5、7天检测两组血清ALB。于确诊为新生儿败血
症时比较两组血清降钙素原(PCT)水平、超敏C 反应蛋白(hs-CRP)水平、白细胞(WBC)计数、血小板(PLT)计数和新生儿危重病
例评分(NCIS)；应用Pearson 相关性分析血清ALB 水平与PCT水平、hs-CRP水平、WBC 计数、PLT计数和NCIS的相关性。新生儿
败血症确诊时绘制92 例患儿血清ALB 水平的受试者工作特征(ROC)曲线,分析其对死亡的预测效果。结果:死亡组血清ALB 在
确诊新生儿败血症时及确诊后的第1、3、5、7天一直维持较低水平,存活组血清ALB上升,且死亡组均低于存活组(P<0.05);确诊
为新生儿败血症时,死亡组血清PCT水平、hs-CRP水平和WBC计数高于存活组,PLT计数和NCIS低于对照组(P<0.05);经过
Pearson相关分析,血清ALB水平与PCT水平、hs-CRP水平和WBC计数呈负相关,与PLT计数、NCIS呈正相关(P<0.05);92例新
生儿败血症患儿血清ALB水平对死亡预测的ROC曲线下总面积为0.878,21.17 g/L为血清ALB的最佳阈值,灵敏度为87.63%,
特异性为100%。结论:血清ALB水平可作为新生儿败血症预后判断指标,为后期临床治疗提供依据。 |
| 关键词: 血清白蛋白 新生儿 败血症 预后 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2017.05.002 |
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| 基金项目: |
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| Prognostic Significance of Serum Albumin in Neonatal Septicemia |
| Yang Jiemei, Zeng Rong, Wang Mokui |
| (The First People's Hospital of Yibin, Sichuan Yibin 644000, China) |
| Abstract: |
| Objective: To explore the prognostic significance of serum albumin (ALB) in neonatal septicemia. Methods: According to
the prognosis, 92 cases of neonatal septicemia were divided into two groups: survival group (n=62) and death group (n=30). The
serum ALB of two groups were detected when neonatal septicemia was diagnosed and confirmed after 1, 3, 5 and 7 d. Compared the two
groups of serum calcitonin (PCT), high sensitive C reactive protein (hs-CRP), white blood cell (WBC), platelet (PLT) and neonatal
critical illness score (NCIS) in the diagnosis of neonatal septicemia. Pearson correlation was used to analyze the correlation of serum
ALB, PCT, hs-CRP, WBC, PLT and NCIS. Receiver operating characteristic (ROC) curve of serum ALB value was used to predict
death for 92 neonatal septicemia children when septicemia was diagnosed. Results: Death group of serum ALB in the diagnosis of
neonatal septicemia and after the diagnosis of 1, 3, 5, 7 d maintained at a low level, the survival group of serum ALB increased, and
the death group were lower than survival group (P<0.05). The serum PCT, hs-CRP and WBC of death group were higher than survival
group, PLT and NCIS were lower than survival group (P<0.05). The Pearson correlation analysis showed that the serum levels of ALB
were negatively correlated with PCT, hs-CRP and WBC in the diagnosis of neonatal septicemia, and positively correlated with PLT and
NCIS (P<0.05). Ninety two cases of neonatal septicemia children with serum ALB level of mortality prediction of the total area under
the ROC curve was 0. 878, 21. 17 g/L for the best threshold of serum ALB, sensitivity was 87. 63%, specificity was 100%.
Conclusion:Serum ALB value can be used as a prognostic indicator in neonatal septicemia, which provides a basis for clinical
treatment. |
| Key words: serum albumin neonatal septicemia prognosis |
