| 摘要: |
| 目的：探讨口服咪达唑仑对接受局部麻醉牙齿修复治疗患儿唾液皮质醇水平的影响。方法：选取2012年4月至2015年12月于我院接受局部麻醉牙齿修复的患儿104例为研究对象，随机分为A、B两组各52例。A组患儿给予口服10 mg/kg咪达唑仑糖浆，B组患儿给予口服同等剂量的安慰剂，监测患儿入院前一天晨起时、入院当日晨起时、入院时、麻醉后25 min及修复治疗后25 min的唾液皮质醇水平，记录患儿的心率及血氧饱和度等参数，评估患儿的行为表现。结果：A组患儿接受咪达唑仑麻醉后25 min的唾液皮质醇水平为（0.48±0.19）μg/dL，低于B组的（1.06±0.21）μg/dL，差异有统计学意义（P<0.05）。其他时间点唾液皮质醇水平组间比较差异无统计学意义（P>0.05），且麻醉方式对患儿唾液皮质醇含量无明显影响。在麻醉和治疗期间，唾液皮质醇水平与患儿挣扎状态（俄亥俄州立大学行为评定量表法）无显著相关性（P>0.05）。结论：口服咪达唑仑能够降低牙齿修复术患儿局部麻醉期间唾液皮质醇水平，但不影响患儿的临床行为。 |
| 关键词: 咪达唑仑 唾液 皮质醇 局部麻醉 牙齿修复 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2017.07.007 |
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| 基金项目: |
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| Midazolam on Salivary Cortisol Levels in Children During Dental Restoration with Local Anaesthesia |
| Xue Wei1, Dong Haiwen2, Zhang Fengjuan1 |
| (1. Baoji People's Hospital of Shaanxi Province, Shaanxi Baoji 721001, China; 2. Baoji Stomatological Hospital, Shaanxi Baoji 721001, China) |
| Abstract: |
| Objective: To investigate the effect of oral midazolam on salivary cortisol levels in children during dental restoration with local anaesthesia. Methods: 104 children received the dental restoration with local anaesthesia in our hospital from April 2012 to December 2015 were chosen in this study, and randomly divided in to group A and B with each group 52 children. Children in group A received oral 1.0 mg/kg midazolam syrup and those in group B received oral placebo syrup with same volume. The salivary cortisol levels when the child woke up at and prior to the dental appointment, 25 minutes after anaesthesia and 25 minutes after the treatment. Heat rate, oxygen saturation and behavior of children were assessed and recorded. Results: The salivary cortisol levels of children in group A 25 minutes after the midazolam anaesthesia were lower than that in group B (0.48±0.19 vs 1.06±0.21), with the statistically significant difference (P<0.05). There were no significant between-group difference at other time periods, and anaesthesia method had no effect on the children’s salivary cortisol levels. During the anaesthesia and treatment, salivary cortisol levels were not related with the children’s struggling behavior (percentage of OSUBRS score 4, P>0.05). Conclusion: Oral midazolam is able to reduce the salivary cortisol levels of children during dental restoration with local anaesthesia, but does not affect the children’s clinical behavior. |
| Key words: midazolam saliva cortisol local anaesthesia dental restoration |
