| 摘要: |
| 目的:总结分析我院儿童患者使用维生素K1注射液所致不良反应(ADR)情况,促进临床安全用药。方法:选取2007年1月至2016年5月在我院住院部接受治疗使用维生素K1注射液发生不良反应的患儿44例为研究对象,对患儿年龄、用法用量、ADR发生时间、临床表现等资料进行回顾性分析。结果:维生素K1注射液所致不良反应最常见的是皮肤及附件损害,静脉给药引起的ADR占97.73%,97.73%的ADR发生在用药后30 min内,44例不良反应中有10例为严重不良反应,均发生在用药后10 min内。结论:为减少不良反应发生,临床使用维生素K1注射液时应加强合理用药,避免无适应证用药;注意配伍禁忌,减少药物联用;严格规范药物贮藏;在用药过程中,注意观察不良反应症状发生情况。 |
| 关键词: 维生素K1 儿童 不良反应 |
| DOI：10.13407/j.cnki.Jpp.1672-108X.2017.09.014 |
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| 基金项目: |
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| Adverse Reactions of Vitamin K1 Injection in 44 Children |
| He Limei, Li Jing, Yang Zhi, Peng Cuiying |
| (Children's Hospital of Hunan Province, Hunan Changsha 410007, China)) |
| Abstract: |
| Objective: To investigate the adverse reactions of vitamin K1 injection in our hospital, and promote medication safty in clinic. Methods: In-patients in our hospital who had adverse reactions caused by vitamin K1 injection from January, 2007 to May, 2016 as research objects were selected, the data were analyzed retrospectively. Results: The most common adverse reaction caused by vitamin K1 injection was the skin and accessories damage. ADR caused by intravenous administration was account for 97.73%, occurred within
30 min after medication. There were 10 cases of serious adverse events in forty-four cases of adverse reactions, had occurred within 10 minutes after medication. Conclusion: In order to reduce adverse reactions, vitamin K1 injection should be used rationally to indications, avoided incompatibility, reduced drug combination. Adverse reactions should be monitored when using vitamin K1. |
| Key words: vitamin K1 children adverse reactions |
