| 摘要: |
| 目的:探讨儿童流感病毒肺炎的有效治疗方案。方法:选取我院2021 年10 月-2022 年10 月收治的流感病毒肺炎患儿
100 例,按随机数表法分为观察组和对照组各50 例。对照组实施帕拉米韦氯化钠注射液治疗,而观察组给予连花清瘟颗粒口
服联合帕拉米韦氯化钠注射液治疗。比较两组患儿主要临床症状缓解时间、血清炎症因子、免疫因子水平以及临床疗效。结
果:观察组发热、咳嗽咳痰、咽痛、流鼻涕、喘息以及肺部湿啰音缓解时间均短于对照组(P<0. 05)。治疗后,观察组降钙素原
(PCT)、肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6 及CD8+水平均低于照组(P<0. 05);IgA、IgG 及CD4+水平均高于对照组(P<
0. 05)。观察组的总有效率(96. 00%)高于对照组(84. 00%,P<0. 05)。结论:连花清瘟颗粒联合帕拉米韦可以有效缓解流感病
毒肺炎患儿的临床症状,减轻炎症反应,增强免疫力。 |
| 关键词: 帕拉米韦 连花清瘟颗粒 流感 肺炎 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2024.05.012 |
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| 基金项目: |
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| Efficacy of Lianhua Qingwen Granules Combined with Peramivir in the Treatment of Influenza VirusPneumonia in Children |
| Zhang Ruyu, Wang Fang |
| (Children’s Hospital Affiliated of Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s
Hospital, Zhengzhou 450000, China) |
| Abstract: |
| Objective: To probe into the effective treatment of influenza virus pneumonia in children. Methods: A total of 100 children
with influenza virus pneumonia admitted into our hospital from Oct. 2021 to Oct. 2022 were extracted to be divided into the observation
group and control group via the random number table method, with 50 cases in each group. The control group was treated with peramivir
sodium chloride injection, while the observation group received oral Lianhua Qingwen granules combined with peramivir sodium chloride
injection. The main clinical symptom remission time, serum inflammatory factors, immune factors and clinical efficacy were compared
between two groups. Results: The remission time of fever, cough, sputum, sore throat, running nose, wheezing and lung moist rale in
the observation group was shorter than that in the control group (P<0. 05). After treatment, the serum levels of procalcitonin (PCT),
tumor necrosis factor (TNF)-α, interleukin (IL)-6 and CD8+ in the observation group were significantly lower than those in the control
group (P<0. 05). The levels of IgA, IgG and CD4+ in the observation group were higher than those in the control group (P<0. 05).
The total effective rate of observation group was 96. 00%, higher than 84. 00% of control group (P <0. 05). Conclusion: Lianhua
Qingwen granules combined with peramivir can effectively relieve the clinical symptoms of children with influenza virus pneumonia,
reduce inflammation and improve immunity. |
| Key words: peramivir Lianhua Qingwen granules influenza pneumonia |
