| 摘要: |
| 目的:了解惠州市第一妇幼保健院儿科门诊超说明书用药情况,并分析对策。方法:随机抽取惠州市第一妇幼保健院2021
年10 月至2022 年9 月儿科门诊处方,依据药品说明书确定是否存在超说明书用药,对超说明书用药发生情况、超说明书用药类
型、主要年龄段及药品种类进行汇总分析。结果:共抽取处方1 556 张,包含用药医嘱4 154 条,基于处方张数和医嘱条数计算出的
超说明书用药发生率分别为36. 70%(571/ 1 556)和43. 98%(1 827/ 4 154)。超说明书用药类型主要是超适应证(27. 09%)、超剂量
(22. 06%)、超频次(19. 27%)。婴幼儿(29 d~3 岁)超说明书用药发生率较高(>40%);超说明书用药发生率居前3 位的药品种类
为内分泌调节剂(59. 86%)、呼吸系统用药(56. 79%)、中成药(53. 95%)。结论:儿科门诊常见超说明书用药,应特别重视婴幼儿用
药;医师应严格依照药品说明书开具处方,国家应制定相关政策规范超说明书用药行为,以保障儿童用药安全。 |
| 关键词: 超说明书用药 儿科 对策 用药安全 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2024.05.005 |
|
| 基金项目:2020年惠州市科技计划(医疗卫生)项目,编号2020Y023。 |
|
| Investigation and Analysis of Off-Label Drug Use in Pediatric Outpatient of a Hospital from 2021 to 2022 |
| Huang Zhiqing1, Yang Yajun1, Li Wenbin2, Wang Chunye2 |
| (1.Guangdong Medical University, Guangdong Zhanjiang
524004, China; 2. Huizhou First Maternal and Child Health Care Hospital, Guangdong Huizhou 516007, China) |
| Abstract: |
| Objective: To investigate the status of off-label drug use in pediatric outpatient of Huizhou First Maternal and Child Health
Care Hospital, and to analyze the countermeasures. Methods: Outpatient prescriptions in Huizhou First Maternal and Child Health
Hospital from Oct. 2021 to Sept. 2022 were randomly selected, and off-label drug use was determined according to drug instructions.
The incidence of off-label drug use, types of off-label drug use, children of different ages and drug categories of off-label drug use were
summarized and analyzed. Results: A total of 1,556 prescriptions were drawn, including 4,154 medication orders, and according to the
number of prescriptions and medication orders, the incidence of off-label drug use was 36.70% (571/ 1,556) and 43.98% (1,827/ 4,154),
respectively. The types of off-label drug use were mainly off-label indication (27. 09%), off-label dosage (22. 06%) and off-label
frequency of administration (19. 27%). The incidence of off-label drug use in infants and young children (from 29 d to 3 years old) was
higher (>40%). Drugs with the highest incidence of off-label drug use were endocrine regulator (59. 86%), respiratory medicines
(56. 79%) and Chinese patent medicines (53. 95%). Conclusion: Off-label drug use in pediatric outpatient is relatively common.
Special attention should be paid to the use of medicines for infants and young children. Clinicians are supposed to issue prescriptions in
strict accordance with the drug instructions, and the state should formulate relevant policies to regulate the behavior of off-label drug use
in order to guarantee the medication safety for children. |
| Key words: off-label drug use pediatrics countermeasures medication safety |
