| 摘要: |
| 目的：探讨乌司他丁对慢性心力衰竭患儿炎症介质､T细胞亚群及心功能的影响｡方法：将80例心力衰竭患儿随机分为观察组和对照组各40例。对照组仅接受常规抗心衰治疗，观察组在常规治疗基础上加用乌司他丁，观察治疗前后两组C反应蛋白（CRP）、脑钠尿肽（BNP）水平、T细胞亚群、心功能指标的变化。结果：治疗后观察组较对照组患儿的CRP、BNP水平明显降低（t分别为3.58、4.28，P<0.01)，左室射血分数升高（t=4.53，P<0.01），CD4+ T细胞及CD4+/CD8+细胞的比例均显著升高（t分别为2.68、2.55，P<0.05)。结论：在常规抗心衰治疗的基础上加用乌司他丁，能显著提高慢性心力衰竭患儿的细胞免疫能力，减轻其炎症反应。 |
| 关键词: 乌司他丁 心力衰竭 儿童 C-反应蛋白 脑钠尿肽 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.05.001 |
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| 基金项目: |
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| Effect of Ulinastatin on CRP and T-lymphocyte Subsets in Children with Chronic Heart Failure |
| Lv guiping |
| (Traditional Chinese and Western Medicine Hospitals of Guangzhou, Guangzhou 510800, China) |
| Abstract: |
| Objective: To investigate the rapeutic effect of ulinastatin on T-lymphocy tesubsets, inflammatory mediator and cardiac function in children with chronic heart failure. Methods: 80 patients receiving conventional treatment were randomly allocated to either observation group (n=40) or control group (n=40). Changes in the plasm C-reactive protein (CRP), T-lymphocyte subsets, brain natriuretic peptide (BNP) level conditions of the were observed in these CHF patients before and after treatment. Results: In observation group, obvious increase of plasma levels of CD4+ T cell and ratio of CD4+ /CD8+ T cell (t=2.68, t=2.55, P<0.05), as well as significant decrease of expression of CRP and BNP were observed (t=3.58, t=4.28, P<0.01) . LVEF improved (t=4.53, P<0.01) compared with those in the control group. Conclusion: Conventional treatment plus ulinastatin, significantly improves the immune condition and reduces the inflamma to ryreaction in children with chronic heart failure. |
| Key words: ulinastatin chronic heart failure children c-reactive protein brain natriuretic peptide |
