| 摘要: |
| 目的：探讨甘露醇联合高渗盐水在小儿颅内感染降颅压中的疗效。方法：将本院2012-2014年收治的106例颅内感染患儿，随机分为A、B、C三组，A组给予20%甘露醇注射液q 4 h降颅压，B组给予20%甘露醇q 6 h降颅压，C组给予20%甘露醇q 6 h+3%高渗盐水q 12 h，比较三组患儿治疗后5 d的脑脊液压力变化、临床症状改善情况、不良反应等。结果：A组病例在脑脊液压力下降、颅内高压临床症状改善方面优于B组（P<0.05）；C组降颅压效果与A组比较差异无统计学意义（P>0.05）。A组肾功损害和电解质紊乱发生率明显高于B组和C组（P<0.05）， C组与B组肾功损害发生率比较差异无统计学意义（P>0.05），但C组电解质紊乱发生率低于B组（P<0.05），结论：甘露醇联合高渗盐水在治疗小儿颅内感染中与传统单用甘露醇相比，在降低颅内压及改善颅内高压临床症状上有较好的疗效，并且肾功损害和电解质紊乱等不良反应发生率低。 |
| 关键词: 甘露醇 高渗盐水 颅内感染 颅内高压 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.11.009 |
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| 基金项目: |
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| Effect of Mannital Combined with Hypertonic Saline on the Treatment of Intracranial Hypertension for Children with Intracranial Infection |
| Xie Lunyan, Shi Mingfang |
| (The First People’S Hospital of Yibin City, Sichuan Yibin 646000, China) |
| Abstract: |
| Objective: To discuss the effect of mannital combined with hypertonic saline on decreasing the intracranial pressure in children with intracranial infection. Methods: 106 children with intracranial infection admitted to hospital in 2012-2014 were prospective analysed. According to medication, they were divided into group A (n=34) treated with mannitol q 4 h, group B (n=36) treated with mannitol q 6 h, and group C (n=36) treated with mannital q 6 h combined with hypertonic saline. We compared the differences of intracranial pressure decreasing, improvement of clinical symptoms, and adverse reactions caused by medication between the three groups after 5 day’s treatment. Results: Group A have better effect on intracranial pressure decreasing and improvement of clinical symptoms than group B (P<0.05), but the incidence of adverse reactions in group A is higher than that in group B (P<0.05). There are no obvious differences between group C and group A (P>0.05), but the incidence of adverse reactions in group C is significantly lower than that in group A (P<0.05).Conclusion: The efficacy of mannital combined with hypertonic saline on reducing CSF pressure and improving clinical symptoms of intracranial hypertension is better than that of traditional mannitol alone in children with intracranial infection, and there are fewer chances to develop into renal dysfunction and electrolyte disturbance. |
| Key words: mannitol hypertonic saline intracranial infection intracranial hypertension |
