| 摘要: |
| 目的:观察健胃消食口服液联合多潘立酮对功能性消化不良(FD)患儿胃肠动力的影响,并分析其临床疗效。方法:收集我院2015年6月至2017年1月治疗的FD患儿156例,使用随机数字表法分为对照组和观察组各78例。对照组口服多潘立酮每次0.3 mg/kg,3 次/天,14 d为一疗程。观察组在对照组基础上加用健胃消食口服液,5~10 mL/次,3 次/天,14 d为一疗程。胃泌素(GAS)、生长抑素(SS)使用ELISA法检测,胃窦排空率使用超声显像测定。比较两组患儿临床疗效和不良反应。结果:治疗前两组患儿GAS和SS比较差异无统计学意义(P>0.05),治疗后观察组GAS[(195.64±35.27) ng/L] 高于对照组
[(169.84±31.25)ng/L],治疗后观察组SS[(21.43±4.16) ng/L ]低于对照组[(27.38±5.07)ng/L,P<0.05)]。清晨标准试验餐后30 min、60 min 和90 min观察组胃窦排空率均高于对照组(P<0.05)。观察组临床治疗有效率为92.3%,高于对照组的75.6%(P<0.05)。观察组不良反应发生率为5.1%,对照组为6.4%,两组比较差异无统计学意义(P>0.05)。结论:健胃消食口服液联合多潘立酮可以显著增加FD患儿的胃肠动力,临床疗效显著,使用安全。 |
| 关键词: 健胃消食口服液 多潘立酮 功能性消化不良 儿童 胃肠动力 |
| DOI：doi: 10.13407/j.cnki.jpp.1672-108X.2017.12.011 |
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| 基金项目: |
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| Jianwei Xiaoshi Oral Liquid Combined with Domperidone on Gastrointestinal Motility in Children with Functional Dyspepsia |
| Wang Qiuying, Chen Kun |
| (Suzhou Municipal Hospital, Anhui Suzhou 234000, China) |
| Abstract: |
| Objective: To observe the effect and clinical effect of Jianwei Xiaoshi oral liquid combined with domperidone on gastrointestinal motility in children with functional dyspepsia (FD). Methods: A total of 156 FD children were enrolled in this study. Using random number table method, the children were divided into control group and observation group, and 78 cases in each group. The control group was treated with domperidone 0.3 mg/kg per time, 3 times/d for 14 d. The observation group on the base of control group was given Jianwei Xiaoshi oral liquid 5~10 mL/times, 3 times/d for 14 d. Gastrin (GAS) and somatostatin (SS) were detected by ELISA assay. The gastric emptying rate was determined by ultrasonic imaging. The clinical effect and adverse reactions were compared. Results: There was no significant difference in GAS and SS between the two groups before treatment (P>0.05). After treatment, GAS ((195.64±35.27) ng/L vs. (169.84±31.25) ng/L) in observation group was significantly higher and SS ((21.43±
4.16) ng/L vs. (27.38±5.07) ng/L) was significantly lower than those in control group (P<0.05). In observation group, the gastric emptying rates were higher than those of control group at 30 min, 60 min, and 90 min (P<0.05). The clinical effective of observation group (92.3%) was significantly higher than that of control group (75.6%, P<0.05). The adverse reactions rate of observation group (5.1%) was significantly lower than that of control group (6.4%, P>0.05). Conclusion: Jianwei Xiaoshi oral liquid combined with domperidone can increase gastrointestinal motility in FD children, with effectively clinical efficacy and safety. |
| Key words: Jianwei Xiaoshi oral liquid domperidone functional dyspepsia children gastrointestinal motility |
