| 摘要: |
| [摘要] 目的:探讨新生儿B族溶血性链球菌(GBS)败血症的围生期临床特征,提高对本病的认识和治疗水平。方法:收集 2011
年5月至2016年5月我院收治的34例新生儿GBS败血症的资料,回顾性分析患儿的发病率、围产期因素、临床表现、实验室及
影像学检查结果、抗生素应用情况。结果:我院分娩的新生儿早发型 GBS 败血症发生率为0.02% ,我院新生儿科住院患儿 GBS
败血症发生率为0.12%,其中早发型0.08% ,晚发型0.05%。早发型多以呻吟、气促等呼吸窘迫症状为临床表现,61.9% 需呼
吸支持;晚发型多以发热、精神反应差为临床表现,53.8% 合并化脓性脑膜炎。 晚发型 GBS 败血症各种抗生素使用总时间
(DOT)与抗生素使用时间(LOT)显著长于早发型 GBS 败血症,且万古霉素使用率显著升高。结论:新生儿GBS感染危害严重,
对孕妇进行孕中、晚期 GBS 感染筛查非常必要,尤其是胎膜早破、有早产倾向者。应重视 GBS 败血症围生期高危因素和早期临
床表现,尽早行病原学检查,合理选择敏感抗生素治疗可有效降低 GBS 败血症患儿病死率。 |
| 关键词: B 族链球菌 败血症 抗生素 新生儿 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.04.006 |
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| 基金项目: |
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| Clinical Analysis of 34 Cases of Neonatal Group B Streptococcus |
| Liu Hongyan, Zhang Shasha, Hu Changxia, Xia Shiwen |
| (Hubei Maternal and Child Health Hospital, Hubei Wuhan 430070,China) |
| Abstract: |
| [Abstract] Objective: To study the clinical features of neonatal group B Streptococcus (GBS) infection in the perinatal period, and
raise the understanding and the treatment level of the disease. Methods: Neonatal data of our hospital from May 2011 to May 2016 were
collected, 34 cases were retrospectively analyzed the incidence of children with GBS infection, perinatal factors, clinical manifestations,
results of laboratory and imaging examination, application of antibiotics. Results: The incidence of early-onset GBS sepsis in our hospital
was 0.02% , the incidence of GBS sepsis in NICU of our hospital was 0.12% , among them, early-onset was 0.08% , late onset was
0.05%. And early-onset, shortness of breath and other symptoms of respiratory distress for the clinical manifestations need more
respiratory support (61.9% ), late-onset with fever and poor mental reaction for the clinical manifestations were more likely to merge
meningitis (53.8% ). Late-onset GBS sepsis antibiotics use days of therapy ( DOT) and length of therapy ( LOT) were significantly
longer than early鄄onset, and a significant rise in vancomycin utilization. Conclusion: GBS infection of neonatal is serious, and it is
necessary to receive GBS screening in midtrimester and last trimester, premature rupture of membranes and prone to premature birth
particularly. We should pay attention to risk factors in the perinatal period and early clinical manifestations, etiology detection should be
taken as early as possible, and reasonably choosing sensitive antibiotic treatment can effectively reduce the mortality. |
| Key words: group B Streptococcus sepsis antibiotics neonate |
