| 摘要: |
| 目的:比较两种常用益生菌制剂对早产儿坏死性小肠结肠炎(NEC)发生率和病死率的影响。方法:选择2016-2017年在我院出生的早产儿167例,随机分为A 组84例和B组83例,分别给予双歧杆菌四联活菌片(0.25 g,1次/天)和双歧杆菌活菌散(0.50 g,1次/天),连续服用至出院。比较两组患儿的病死率、Ⅱ期及以上NEC发生率、败血症发生率、全胃肠饮食(TPN)时间、住院时间、喂养不耐受次数。结果:A组和B组患儿服药时间分别为36(28,49)d 和40(26,52)d,差异无统计学意义(P>0.05);病死率分别为4郾76%(4/84)和16.87%(14/83),差异有统计学意义(P<0.05)。A组NEC、败血症死亡比例小于B组(P<0.05);A组Ⅱ期及以上NEC发生率、TPN时间、喂养量达100 mL/d 及150 mL/d 的时间、喂养不耐受次数、喂养不耐受>3次比例均小于或短于B组(P均<0.05);两组患儿败血症发生率、住院时间比较差异均无统计学意义(P均>0.05)。结论:双歧杆菌四联活菌片能有效降低早产儿NEC的发生率和病死率,疗效优于双歧杆菌活菌散。 |
| 关键词: 早产儿 坏死性小肠结肠炎 益生菌 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2019.06.010 |
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| 基金项目: |
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| Comparison of Two Kinds of Probiotics in Prevention of Necrotizing Enterocolitis in Premature Infants |
| Li Cuilian |
| (Shangqiu Traditional Chinese Medicine Hospital, Henan Shangqiu 476000, China) |
| Abstract: |
| Objective: To compare the effects of two kinds of probiotics on incidence and mortality of necrotizing enterocolitis (NEC)
in premature infants. Methods: Totally 167 premature infants born in our hospital from 2016 to 2017 were extracted to be randomly
divided into group A (n=84) and group B (n=83), and bifidobacterium tetrad viable tablets (0.25 g, once a day) and
bifidobacterium viable powder (0.5 g, once a day) were given respectively for continuous use until discharge. The mortality,
incidence of NEC ≥stage Ⅱ, incidence of septicemia, total parenteral nutrition (TPN) time, length of stay and feeding intolerance
frequency were compared between two groups. Results: The medication time in group A and group B were respectively 36 (28, 49) d
and 40 (26, 52) d, and the difference was not statistically significant (P>0.05); the mortality rate was respectively 4.76% (4/84) and 16.87% (14/83), the difference was statistically significant (P<0.05). The proportion of death caused by NEC and sepsis in group A was lower than that in group B (P<0.05). The incidence of NEC ≥stage Ⅱ, TPN time, time of feeding amount to 100 mL/d and
150 mL/d, feeding intolerance frequency and feeding intolerance>3 times in group A were less than or shorter than those in group B
(P<0.05). There was no statistically significant difference between two groups in incidence of sepsis and length of stay (P>0.05).
Conclusion: Bifidobacterium tetra viable tablets can effectively reduce the incidence and mortality of NEC, and its efficacy is better than bifidobacterium viable powder. |
| Key words: premature infants necrotizing enterocolitis probiotics |
