| 摘要: |
| 目的：探讨茵栀黄口服液辅助肝门空肠吻合术治疗新生儿胆道闭锁的临床效果。方法：选择2015年3月至2018年1月我院收治并确诊的胆道闭锁新生儿120例。根据随机字母表法将新生儿分为观察组和对照组，每组60例。对照组采用肝门空肠吻合术治疗，观察组采用茵栀黄口服液联合肝门空肠吻合术治疗，比较两组的疗效、血生化指标（TBIL、AST和ALT）、肝纤维化指标（LN、HA、PC-Ⅲ和Ⅳ-C）、细胞因子（IL-18、TNF-α和TGF-β）和不良反应。结果：治疗1年后，观察组有效率90.00%，高于对照组的75.00%（P<0.05）。治疗1年后，观察组的TBIL、AST、ALT、LN、HA、PC-Ⅲ、Ⅳ-C、IL-18、TNF-α和TGF-β水平均低于对照组（P<0.05）。两组不良反应发生率比较差异无统计学意义（P>0.05）。结论：与肝门空肠吻合术单独治疗相比，茵栀黄口服液辅助肝门空肠吻合术治疗胆道闭锁的疗效更好 |
| 关键词: 胆道闭锁 新生儿 肝门空肠吻合术 茵栀黄口服液 肝纤维化 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2021.07.003 |
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| 基金项目: |
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| Clinical Effects of Yinzhihuang Oral Liquid Combined with Kasai Portoenterostomy in the Treatment of Neonatal Biliary Atresia |
| Peng Kun, Zhou Chonggao, Xia Renpeng, Zhao Fan, Ma Tidong, Li Bixiang |
| (Hunan Children’s Hospital, Hunan Changsha 410007, China) |
| Abstract: |
| Objective: To probe into the clinical effects of Yinzhihuang oral liquid combined with Kasai portoenterostomy in the treatment of neonatal biliary atresia. Methods: Totally 120 neonates with biliary atresia admitted to our hospital from Mar. 2015 to Jan. 2018 were selected to be divided into the observation group and the control group via the random number table, with 60 cases in each group. The control group was given Kasai portoenterostomy, while the observation group received Yinzhihuang oral liquid combined with Kasai portoenterostomy. Efficacy, blood biochemical indicators such as total bilirubin (TBIL), aspartic transaminase (AST) and alanine aminotransferase (ALT), liver fibrosis indicators such as laminin (LN), hyaluronic acid (HA), procollagen Ⅲ (PC-Ⅲ) and type Ⅳ collagen (Ⅳ-C), cytokines such as interleukin (IL)-18, tumour necrosis factor (TNF)-α and transforming growth factor (TGF)-β and adverse drug reactions of two groups were compared. Results: After one year of treatment, the effective rate of the observation group was 90.00%, higher than 75.00% of the control group (P<0.05). After one year of treatment, the levels of TBIL, AST, ALT, LN, HA, PC-Ⅲ, Ⅳ-C, IL-18, TNF-α and TGF-β in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse drug reactions between two groups (P>0.05). Conclusion: Compared with Kasai portoenterostomy alone, the efficacy of Yinzhihuang oral liquid combined with Kasai portoenterostomy in the treatment of biliary atresia is more remarkable |
| Key words: biliary atresia neonates Kasai portoenterostomy Yinzhihuang oral liquid liver fibrosis |
